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  Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis

Wei, P., Ye, Z., Cao, S., Bai, S., Seeberger, P. H., Yin, J., et al. (2020). Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 598: 124804. doi:10.1016/j.colsurfa.2020.124804.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-4D0A-A Version Permalink: http://hdl.handle.net/21.11116/0000-0006-9EEC-F
Genre: Journal Article

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Article.pdf (Publisher version), 2MB
 
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 Creators:
Wei, Peng, Author
Ye, Zhou, Author
Cao, Shuya, Author
Bai, Shuo, Author
Seeberger, Peter H.1, Author              
Yin, Jian, Author
Hu, Jing, Author
Affiliations:
1Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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Free keywords: Nanomicelle, Leishmaniasis, Mannose receptor
 Abstract: Drugs used to treat visceral leishmaniasis (VL) have severe side effects and face increasing resistance. We have created a mannose-functionalized nanomicelle carrying two drugs amphotericin B (AmB) and doxorubicin (DOX). The nanomicelles AmB&DOX@MCC preferentially target macrophages where Leishmania parasites reside and replicate, by the interaction between mannose residues on the micelle and mannose receptors (MRs) on the macrophage membrane. The combination of AmB and DOX leads to enhanced anti-leishmanial therapeutic efficacy through a synergistic effect. The mannose-fabricated nanomicelle is a promising formulation for leishmaniasis treatment.

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Language(s): eng - English
 Dates: 2020-04-122020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.colsurfa.2020.124804
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Title: Colloids and Surfaces A: Physicochemical and Engineering Aspects
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 598 Sequence Number: 124804 Start / End Page: - Identifier: ISSN: 0927-7757