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  Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle

Hubbard, A. T. M., Newire, E., Botelho, J., Reiné, J., Wright, E., Murphy, E. A., et al. (2020). Isolation of an antimicrobial-resistant, biofilm-forming, Klebsiella grimontii isolate from a reusable water bottle. MicrobiologyOpen, n/a(n/a): e1023. doi:10.1002/mbo3.1023.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-4E33-A Version Permalink: http://hdl.handle.net/21.11116/0000-0006-4E36-7
Genre: Journal Article

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 Creators:
Hubbard, Alasdair T. M., Author
Newire, Enas, Author
Botelho, João1, Author              
Reiné, Jesús, Author
Wright, Elli, Author
Murphy, Emma A, Author
Hutton, William, Author
Roberts, Adam P., Author
Affiliations:
1Max Planck Fellow Group Antibiotic Resistance Evolution, Max Planck Institute for Evolutionary Biology, Max Planck Society, ou_2600692              

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Free keywords: antibiotic resistance, biofilm, environmental, Kleboxymycin, Klebsiella grimontii, water bottle
 Abstract: Abstract A reusable water bottle was swabbed as part of the citizen science project ?Swab and Send,? and a Klebsiella grimontii isolate was recovered on chromogenic agar and designated SS141. Whole-genome sequencing of SS141 showed it has the potential to be a human pathogen as it contains the biosynthetic gene cluster for the potent cytotoxin, kleboxymycin, and genes for other virulence factors. The genome also contains the antibiotic-resistant genes, blaOXY-6-4, and a variant of fosA, which is likely to explain the observed resistance to ampicillin, amoxicillin, and fosfomycin. We have also shown that SS141 forms biofilms on both polystyrene and polypropylene surfaces, providing a reasonable explanation for its ability to colonize a reusable water bottle. With the increasing use of reusable water bottles as an alternative to disposables and a strong forecast for growth in this industry over the next decade, this study highlights the need for cleanliness comparable to other reusable culinary items.

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Language(s): eng - English
 Dates: 2020-01-312019-11-012020-02-142020-03-03
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/mbo3.1023
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Title: MicrobiologyOpen
Source Genre: Journal
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Publ. Info: Malden, Mass. : Wiley
Pages: - Volume / Issue: n/a (n/a) Sequence Number: e1023 Start / End Page: - Identifier: ISSN: 2045-8827
CoNE: https://pure.mpg.de/cone/journals/resource/2045-8827