English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Genes acting in synapses and neuron projections are early targets of selection during urban colonization

Mueller, J. C., Carrete, M., Boerno, S., Kuhl, H., Tella, J. L., & Kempenaers, B. (2020). Genes acting in synapses and neuron projections are early targets of selection during urban colonization. Molecular Ecology, 15451. doi:10.1111/mec.15451.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-4E53-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-4E54-5
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Mueller, Jakob C.1, Author              
Carrete, Martina, Author
Boerno, Stefan2, Author              
Kuhl, Heiner2, Author              
Tella, José L., Author
Kempenaers, Bart1, Author              
Affiliations:
1Abteilung Kempenaers, Seewiesen, Max Planck Institut für Ornithologie, Max Planck Society, ou_2149689              
2Sequencing (Head: Bernd Timmermann), Scientific Service (Head: Christoph Krukenkamp), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_1479670              

Content

show
hide
Free keywords: Strigiformes, selection signature, functional enrichment, GWAS, gene set analysis, synapse, neuron projection
 Abstract: PDFPDF Tools Share Abstract When a species colonizes an urban habitat, differences in the environment can create novel selection pressures. Successful colonization will further lead to demographic perturbations and genetic drift, which can interfere with selection. Here, we test for consistent urban selection signals in multiple populations of the burrowing owl (Athene cunicularia), a species that colonized South American cities just a few decades ago. We sequenced 213 owls from three urban‐rural population pairs and performed a genome‐wide comparison of urban against rural birds. We further studied genome‐wide associations with flight initiation distance (FID), a measure of harm avoidance in which urban and rural birds are known to differ. Based on four samples taken over nine years from one of the urban populations, we investigated temporal allele frequency changes. The genomic data were also used to identify urban‐specific signatures of selective sweeps. Single genomic sites did not reach genome‐wide significance for any association. However, a gene‐set analysis on the strongest signals from these four selection scans suggests a significant enrichment of genes with known functions related to synapses and neuron projections. We identified 98 genes predominantly expressed in the brain, of which many may play a role in the modulation of brain connectivity and consequently in cognitive function and motivational behavior during urbanization. Furthermore, polymorphisms in the promotor region of the synaptic SERT gene – one of the two candidates known to correlate with urban colonization in birds ‐ associated with the habitat in which individuals lived (urban vs. rural).

Details

show
hide
Language(s): eng - English
 Dates: 2020-04-20
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/mec.15451
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Molecular Ecology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: - Sequence Number: 15451 Start / End Page: - Identifier: ISSN: 0962-1083
CoNE: https://pure.mpg.de/cone/journals/resource/954925580119