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  In silico optical control of pinned electrical vortices in an excitable biological medium

Majumder, R., Zykov, V. S., & Panfilov, A. V. (2020). In silico optical control of pinned electrical vortices in an excitable biological medium. New J. Phys., 22: 023034. doi:10.1088/1367-2630/ab704f.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-AC7F-B Version Permalink: http://hdl.handle.net/21.11116/0000-0006-AC80-7
Genre: Journal Article

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Majumder, R.1, Author              
Zykov, V. S.1, Author              
Panfilov, A. V., Author
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1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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 Abstract: Vortices of excitation are generic to any complex excitable system. In the heart, they occur as rotors, spirals (2D) and scroll waves (3D) of electrical activity that are associated with rhythm disorders, known as arrhythmias. Lethal cardiac arrhythmias often result in sudden death, which is one of the leading causes of mortality in the industrialized world. Irrespective of the nature of the excitable medium, the rotation of a rotor is driven by its dynamics at the (vortex) core. In a recent study, Majumder et al (2018 eLife 7 e41076) demonstrated, using in silico and in vitro cardiac optogenetics, that light-guided manipulation of the core of free rotors can be used to establish real-time spatiotemporal control over the position, number and rotation of these rotors in cardiac tissue. Strategic application of this method, called 'Attract-Anchor-Drag' (AAD) can also be used to eliminate free rotors from the heart and stop cardiac arrhythmias. However, rotors in excitable systems, can pin (anchor) around local heterogeneities as well, thereby limiting their dynamics and possibility for spatial control. Here, we expand our results and numerically demonstrate, that AAD method can also detach anchored vortices from inhomogeneities and subsequently control their dynamics in excitable systems. Thus, overall we demonstrate that AAD control is one of the first universal methods that can be applied to both free and pinned vortices, to ensure their spatial control and removal from the heart and, possibly, other excitable systems.

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Language(s): eng - English
 Dates: 2020-02-26
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1088/1367-2630/ab704f
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Title: New J. Phys.
Source Genre: Journal
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Pages: 11 Volume / Issue: 22 Sequence Number: 023034 Start / End Page: - Identifier: -