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  Dynamic coupling of whole-brain neuronal and neurotransmitter systems

Kringelbach, M. L., Cruzat, J., Cabral, J., Knudsen, G. M., Carhart-Harris, R., Whybrow, P. C., et al. (2020). Dynamic coupling of whole-brain neuronal and neurotransmitter systems. Proceedings of the National Academy of Sciences of the United States of America, 117(17), 9566-9576. doi:10.1073/pnas.1921475117.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-52A6-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-52A7-1
Genre: Journal Article

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 Creators:
Kringelbach, Morten L.1, 2, 3, 4, Author
Cruzat, Josephine5, 6, Author
Cabral, Joana2, 3, 4, Author
Knudsen, Gitte Moos7, 8, 9, Author
Carhart-Harris, Robin10, Author
Whybrow, Peter C.4, 11, Author
Logothetis , Nikos K.12, 13, Author
Deco, Gustavo6, 14, 15, 16, Author              
Affiliations:
1Department of Psychiatry, University of Oxford, United Kingdom, ou_persistent22              
2Center for Music in the Brain, Aarhus University, Denmark, ou_persistent22              
3ICVS - Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal, ou_persistent22              
4Centre for Eudaimonia and Human Flourishing, University of Oxford, United Kingdom, ou_persistent22              
5Computational Neuroscience Group, Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
6Department of Information and Communication Technologies, Center for Brain and Cognition, University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
7Neurobiology Research Unit, Rigshospitalet, Copenhagen, Denmark, ou_persistent22              
8Center for Integrated Molecular Brain Imaging (CIMBI), Copenhagen, Denmark, ou_persistent22              
9Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, ou_persistent22              
10Psychedelic Research Group, Division of Brain Sciences, Faculty of Medicine, Imperial College London, United Kingdom, ou_persistent22              
11Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA, ou_persistent22              
12Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ou_persistent22              
13Centre for Imaging Sciences, University of Manchester, United Kingdom, ou_persistent22              
14Catalan Institution for Research and Advanced Studies (ICREA), University Pompeu Fabra, Barcelona, Spain, ou_persistent22              
15Department Neuropsychology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634551              
16School of Psychological Sciences, Monash University, Melbourne, Australia, ou_persistent22              

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Free keywords: Serotonin; PET; Psilocybin; Neurotransmitter; Whole-brain modeling
 Abstract: Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.

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Language(s): eng - English
 Dates: 2019-12-102020-04-132020-04-28
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1073/pnas.1921475117
Other: epub 2020
PMID: 32284420
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
 Creator(s):
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 117 (17) Sequence Number: - Start / End Page: 9566 - 9576 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230