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  Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance

Kermani, F., Gharavian, A., Mollazadeh, S., Kargozar, S., Youssefi, A., & Vahdati Khaki, J. (2020). Silicon-doped calcium phosphates; the critical effect of synthesis routes on the biological performance. Materials Science and Engineering C, 111: 110828. doi:10.1016/j.msec.2020.110828.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-5F8F-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-5F90-D
Genre: Journal Article

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 Creators:
Kermani, F., Author
Gharavian, Amirmasoud1, Author              
Mollazadeh, S., Author
Kargozar, S., Author
Youssefi, A., Author
Vahdati Khaki, J., Author
Affiliations:
1Kerstin Blank, Mechano(bio)chemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2301698              

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Free keywords: Calcium phosphates, Silicon ions (Si) substitution, Solution combustion synthesis, properties, Tissue engineering
 Abstract: In this study, the effect of using different types of fuel and various amounts of Si4+ ions on the biological properties of silicon-doped calcium phosphates (CaPs), which were synthesized using solution combustion method were investigated. X-ray diffraction (XRD) patterns showed that hydroxyapatite/beta-tricalcium phosphate (HA/βTCP) was crystallized in all synthesized samples. The synthesized sample using glycine as fuel, which doped with 0.1 mol Si4+ ions exhibited the most desirable properties. Consecutively, the zeta potential and specific surface area were enhanced from −20 to −27 mV and 38 to 146 m2/g, respectively, by increasing the amount of Si4+ ions from 0 to 0.1 mol. The bioactivity of the samples immersed in simulated body fluid (SBF) was innovatively determined by the joint analyses of the tensiometer, inductively coupled plasma (ICP), field emission scanning electron microscopy (FESEM), and XRD data. These findings plus theoretical calculations demonstrate, for the first time, that the Si4+ doping could improve the bioactivity of the powders up to ~155%. The results of in vitro cell-based experiments, including cell viability, alizarin red staining, and cell attachment, confirmed the positive effects of Si-doped powders in the biological systems. Furthermore, Si-doped powders were able to improve the migration ability of mammalian cells in vitro; they could be considered good candidates in angiogenesis-based therapeutic strategies.

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 Dates: 2020-03-102020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
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Title: Materials Science and Engineering C
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Elsevier
Pages: - Volume / Issue: 111 Sequence Number: 110828 Start / End Page: - Identifier: ISSN: 0928-4931