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  A peptide link between HCMV infection, neuronal migration, and psychosis

Lucchese, G., Flöel, A., & Stahl, B. (2020). A peptide link between HCMV infection, neuronal migration, and psychosis. Frontiers in Psychiatry, 11: 349. doi:10.3389/fpsyt.2020.00349.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-54CA-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-7826-9
Genre: Journal Article

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 Creators:
Lucchese, Guglielmo1, 2, Author
Flöel, Agnes1, 3, Author
Stahl, Benjamin1, 4, 5, Author              
Affiliations:
1Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany, ou_persistent22              
2Department of Computing, Goldsmiths, University College London, United Kingdom, ou_persistent22              
3German Center for Neurodegenerative Diseases, Berlin, Germany, ou_persistent22              
4Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
5Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              

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Free keywords: Peptide sharing; HCMV; Immune response; Schizophrenia; Cross-reactivity
 Abstract: Alongside biological, psychological and social risk factors, psychotic syndromes may be related to disturbances of neuronal migration. This highly complex process characterizes the developing brain of the fetus, the early postnatal brain, and the adult brain, as reflected by changes within the subventricular zone and the dentate gyrus of the hippocampus, where neurogenesis persists throughout life. Psychosis also appears to be linked to human cytomegalovirus (HCMV) infection. However, little is known about the connection between psychosis, HCMV infection, and disruption of neuronal migration. The present study addresses the hypothesis that HCMV infection may lead to mental disorders through mechanisms of autoimmune cross-reactivity. Searching for common peptides that underlie immune cross-reactions, the analyses focus on HCMV and human proteins involved in neuronal migration. Results demonstrate a large overlap of viral peptides with human proteins associated with neuronal migration, such as ventral anterior homeobox 1 and cell adhesion molecule 1 implicated in GABAergic and glutamatergic neurotransmission. The present findings support the possibility of immune cross-reactivity between HCMV and human proteins that—when altered, mutated, or improperly functioning—may disrupt normal neuronal migration. In addition, these findings are consistent with a molecular and mechanistic framework for pathological sequences of events, beginning with HCMV infection, followed by immune activation, cross-reactivity and neuronal protein variations that may ultimately contribute to the emergence of mental disorders, including psychosis.

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Language(s): eng - English
 Dates: 2019-10-212020-04-062020-05-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.3389/fpsyt.2020.00349
Other: eCollection 2020
PMID: 32457660
PMC: PMC7225321
 Degree: -

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Project name : -
Grant ID : 393148499
Funding program : -
Funding organization : German Research Foundation (DFG)
Project name : -
Grant ID : -
Funding program : Open Access Publication Fund
Funding organization : University of Greifswald
Project name : -
Grant ID : -
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: Frontiers in Psychiatry
  Abbreviation : Front Psychiatry
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 349 Start / End Page: - Identifier: ISSN: 1664-0640
CoNE: https://pure.mpg.de/cone/journals/resource/16640640