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  Dissociable neural correlates of stimulation intensity and detection in somatosensation

Forschack, N., Nierhaus, T., Müller, M. M., & Villringer, A. (2020). Dissociable neural correlates of stimulation intensity and detection in somatosensation. NeuroImage, 217: 116908. doi:10.1016/j.neuroimage.2020.116908.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-5765-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-B303-C
Genre: Journal Article

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 Creators:
Forschack, Norman1, 2, Author              
Nierhaus, Till2, 3, Author              
Müller, Matthias M.1, Author
Villringer, Arno2, 4, Author              
Affiliations:
1Department of Experimental Psychology and Methods, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Neurocomputation and Neuroimaging Unit, FU Berlin, Germany, ou_persistent22              
4MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Somatosensory detection; Event-related potentials; Pre-stimulus Rolandic oscillations; Subthreshold electrical stimulation; Regularized logistic regression; Baysian null-hypotheses testing
 Abstract: Somatosensory stimulation intensity and behavioral detection are positively related, and both correlate with neural responses. However, it is still controversial as to what extent stimulus intensity and early somatosensory evoked potentials (SEP) predict detection and how these parameters interact with pre-stimulus brain oscillatory states, which also influence sensory processing. Here we investigated how early SEP components encode stimulation intensity, how pre-stimulus alpha- and beta-band amplitudes interact with SEPs, and which neural markers predict stimulus detection. To this end, we randomly presented electrical finger nerve stimulation with various intensities distributed along the individual psychometric response function (including catch trials) while recording the EEG. Participants reported stimulus presence on a trial-by-trial basis (one-alternative-forced-choice). For the lowest (imperceptible) intensities, participants showed zero (behavioral) sensitivity despite measurable early cortical processing reflected by the P50 component. The P50 amplitude scaled with increasing stimulation intensities but was not predictive of stimulus detection. Instead, detection was associated with the later negative N150 component, as well as with pre-stimulus lowered somatosensory alpha- and increased frontal beta-band amplitudes. Our results give evidence for a serial representation of stimulus intensity and detection, as reflected by the P50 and N150 amplitude, respectively. Furthermore, stimulus detection seems to depend on the current brain state, rendering upcoming stimulation being reportable or not.

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Language(s): eng - English
 Dates: 2020-04-302019-07-262020-05-032020-05-062020-08-15
 Publication Status: Published in print
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 Identifiers: DOI: 10.1016/j.neuroimage.2020.116908
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Title: NeuroImage
Source Genre: Journal
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Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 217 Sequence Number: 116908 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166