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  Mean oxygen saturation during sleep is related to specific brain atrophy pattern

Marchi, N. A., Ramponi, C., Hirotsu, C., Haba‐Rubio, J., Lutti, A., Preisig, M., et al. (2020). Mean oxygen saturation during sleep is related to specific brain atrophy pattern. Annals of Neurology. doi:10.1002/ana.25728.

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 Creators:
Marchi, Nicola Andrea1, 2, Author
Ramponi, Cristina1, Author
Hirotsu, Camila2, Author
Haba‐Rubio, José2, Author
Lutti, Antoine1, Author
Preisig, Martin3, Author
Marques‐Vidal, Pedro4, Author
Vollenweider, Peter4, Author
Kherif, Ferath1, Author
Heinzer, Raphael2, Author
Draganski, Bogdan1, 5, Author              
Affiliations:
1Département des Neurosciences Cliniques, Laboratoire de Recherche en Neuroimagerie (LREN),, ou_persistent22              
2Center for Investigation and Research in Sleep, Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Center for Research in Psychiatric Epidemiology and Psychopathology, Department of Psychiatry, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
4Department of Medicine, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
5Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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 Abstract: Objective There is much controversy about the neurobiological mechanisms underlying the effects of sleep‐disordered breathing on the brain. The aim of this study was to investigate the association between markers of sleep‐related hypoxemia and brain anatomy. Methods We used data from a large‐scale cohort from the general population (n = 775, 50.6% males, age range = 45–86 years, mean age = 60.3 ± 9.9) that underwent full polysomnography and brain magnetic resonance imaging to correlate respiratory variables with regional brain volume estimates. Results After adjusting for age, gender, and cardiovascular risk factors, only mean oxygen saturation during sleep was associated with bilateral volume of hippocampus (right: p = 0.001; left: p < 0.001), thalamus (right: p < 0.001; left: p < 0.001), putamen (right: p = 0.001; left: p = 0.001), and angular gyrus (right: p = 0.011; left: p = 0.001). We observed the same relationship in left hemispheric amygdala (p = 0.010), caudate (p = 0.008), inferior frontal gyrus (p = 0.004), and supramarginal gyrus (p = 0.003). The other respiratory variables—lowest oxygen saturation, percentage of sleep time with oxygen saturation < 90%, apnea–hypopnea index, and oxygen desaturation index—did not show any significant association with brain volumes. Interpretation Lower mean oxygen saturation during sleep was associated with atrophy of cortical and subcortical brain areas known for high sensitivity to oxygen supply. Their vulnerability to hypoxemia may contribute to behavioral phenotype and cognitive decline in patients with sleep‐disordered breathing.

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Language(s): eng - English
 Dates: 2020-03-222019-10-292020-03-232020-03-27
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1002/ana.25728
Other: epub ahead of print
PMID: 32220084
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Title: Annals of Neurology
Source Genre: Journal
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Publ. Info: Boston : American Neurological Association
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0364-5134
CoNE: https://pure.mpg.de/cone/journals/resource/954925523748