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  Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

Beyer, L., Nitschmann, A., Barthel, H., van Eimeren, T., Unterrainer, M., Sauerbeck, J., et al. (2020). Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury. European Journal of Nuclear Medicine and Molecular Imaging. doi:10.1007/s00259-020-04788-w.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-59D2-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-59D3-8
Genre: Journal Article

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 Creators:
Beyer, Leonie, Author
Nitschmann, Alexander, Author
Barthel, Henryk, Author
van Eimeren, Thilo, Author
Unterrainer, Marcus, Author
Sauerbeck, Julia, Author
Marek, Ken, Author
Song, Mengmeng, Author
Palleis, Carla, Author
Respondek, Gesine, Author
Hammes, Jochen, Author
Barbe, Michael T., Author
Onur, Özgür, Author
Jessen, Frank, Author
Saur, Dorothee, Author
Schroeter, Matthias L.1, Author              
Rumpf, Jost-Julian, Author
Rullmann, Michael, Author
Schildan, Andreas, Author
Patt, Marianne, Author
Neumaier, Bernd, AuthorBarret, Olivier, AuthorMadonia, Jennifer, AuthorRussell, David S., AuthorStephens, Andrew W., AuthorRoeber, Sigrun, AuthorHerms, Jochen, AuthorBötzel, Kai, AuthorLevin, Johannes, AuthorClassen, Joseph, AuthorHöglinger, Günter U., AuthorBartenstein, Peter, AuthorVillemagne, Victor, AuthorDrzezga, Alexander, AuthorSeibyl, John, AuthorSabri, Osama, AuthorBrendel, Matthias, Author more..
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Tau; PET; [18F]PI-2620; Perfusion; Neuronal injury
 Abstract: Purpose Second-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG). Methods Twenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers. Results Highest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers. Conclusion Early-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.

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Language(s): eng - English
 Dates: 2020-01-022020-03-242020-04-21
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1007/s00259-020-04788-w
Other: epub ahead of print
PMID: 32318783
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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624