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  Biocompatible magnetic micro‐ and nanodevices: fabrication of FePt nanopropellers and cell transfection

Kadiri, V. M., Bussi, C., Holle, A. W., Son, K., Kwon, H., Schütz, G., et al. (2020). Biocompatible magnetic micro‐ and nanodevices: fabrication of FePt nanopropellers and cell transfection. Advanced Materials, 2001114, pp. 1-9. doi:10.1002/adma.202001114.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-5A9E-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-5AA5-B
Genre: Journal Article

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https://doi.org/10.1002/adma.202001114 (Any fulltext)
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 Creators:
Kadiri, Vincent Mauricio, Author
Bussi, Claudio, Author
Holle, Andrew W.1, Author              
Son, Kwanghyo, Author
Kwon, Hyunah, Author
Schütz, Gisela, Author
Gutierrez, Maximiliano G., Author
Fischer, Peer, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              

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Free keywords: biocompatible magnetic materials ; FePt ; gene delivery ; iron platinum ; magnetic nanopropellers ; nano‐ and micromotors
 Abstract: The application of nanoparticles for drug or gene delivery promises benefits in the form of single‐cell‐specific therapeutic and diagnostic capabilities. Many methods of cell transfection rely on unspecific means to increase the transport of genetic material into cells. Targeted transport is in principle possible with magnetically propelled micromotors, which allow responsive nanoscale actuation and delivery. However, many commonly used magnetic materials (e.g., Ni and Co) are not biocompatible, possess weak magnetic remanence (Fe3O4), or cannot be implemented in nanofabrication schemes (NdFeB). Here, it is demonstrated that co‐depositing iron (Fe) and platinum (Pt) followed by one single annealing step, without the need for solution processing, yields ferromagnetic FePt nanomotors that are noncytotoxic, biocompatible, and possess a remanence and magnetization that rival those of permanent NdFeB micromagnets. Active cell targeting and magnetic transfection of lung carcinoma cells are demonstrated using gradient‐free rotating millitesla fields to drive the FePt nanopropellers. The carcinoma cells express enhanced green fluorescent protein after internalization and cell viability is unaffected by the presence of the FePt nanopropellers. The results establish FePt, prepared in the L10 phase, as a promising magnetic material for biomedical applications with superior magnetic performance, especially for micro‐ and nanodevices.

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Language(s): eng - English
 Dates: 2020-03-232020-02-172020-05-06
 Publication Status: Published online
 Pages: 9
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1002/adma.202001114
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Title: Advanced Materials
  Other : Adv. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH
Pages: - Volume / Issue: - Sequence Number: 2001114 Start / End Page: 1 - 9 Identifier: ISSN: 0935-9648
CoNE: https://pure.mpg.de/cone/journals/resource/954925570855