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  Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana

Thirumalaikumar, V. P., Wagner, M., Balazadeh, S., & Skirycz, A. (2021). Autophagy is responsible for the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis thaliana. The FEBS Journal, 288(1), 281-292. doi:10.1111/febs.15336.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-AABF-3 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-AAD6-8
Genre: Journal Article

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Thirumalaikumar, V. P.1, Author              
Wagner, M.2, Author              
Balazadeh, S.1, Author              
Skirycz, A.2, Author              
Affiliations:
1Stress Control Networks, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2435691              
2Small-Molecule Signalling, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_2586692              

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Free keywords: autophagy, dipeptides, heat stress
 Abstract: Proteogenic dipeptides are intermediates of proteolysis as well as an emerging class of small-molecule regulators with diverse and often dipeptide-specific functions. Herein, prompted by differential accumulation of dipeptides in a high-density Arabidopsis thaliana time-course stress experiment, we decided to pursue an identity of the proteolytic pathway responsible for the buildup of dipeptides under heat conditions. By querying dipeptide accumulation versus available transcript data, autophagy emerged as a top hit. To examine whether autophagy indeed contributes to the accumulation of dipeptides measured in response to heat stress, we characterized the loss-of-function mutants of crucial autophagy proteins to test whether interfering with autophagy would affect dipeptide accumulation in response to the heat treatment. This was indeed the case. This work implicates the involvement of autophagy in the accumulation of proteogenic dipeptides in response to heat stress in Arabidopsis.

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/febs.15336
BibTex Citekey: doi:10.1111/febs.15336
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Title: The FEBS Journal
  Other : The Federation if European Biochemical Societies Journal
Source Genre: Journal
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Publ. Info: Wiley-Blackwell
Pages: - Volume / Issue: 288 (1) Sequence Number: - Start / End Page: 281 - 292 Identifier: ISSN: 1742-464X
CoNE: https://pure.mpg.de/cone/journals/resource/954925398485