English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Metabolism and acetylation in innnate immune cell function and fate

Cameron, A. M., Lawless, S. J., & Pearce, E. J. (2016). Metabolism and acetylation in innnate immune cell function and fate. Seminars in Immunology, 28, 408-416. doi:org/10.1016/j.smim.2016.10.003.

Item is

Files

show Files
hide Files
:
Cameron et al..pdf (Publisher version), 2MB
 
File Permalink:
-
Name:
Cameron et al..pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Cameron , Alanna M.1, Author
Lawless, Simon J.1, Author
Pearce, Edward J.1, Author           
Affiliations:
1Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243648              

Content

show
hide
Free keywords: Immunometabolism; Acetylation; Innate immunity; Macrophages; Dendritic cells
 Abstract: Innate immunity is the first line of defense against invading pathogens. Changes in both metabolism and chromatin accessibility contribute to the shaping of these innate immune responses, and we are beginning to appreciate that cross-talk between these two systems plays an important role in determining innate immune cell differentiation and function. In this review we focus on acetylation, a post-translational modification important for both regulating chromatin accessibility by modulating histone function, and for functional regulation of non-histone proteins, which has many links to both immune signaling and metabolism. We discuss the interactions between metabolism and acetylation, including the requirement for metabolic intermediates as substrates and co-factors for acetylation, and the regulation of metabolic proteins and enzymes by acetylation. Here we highlight recent findings, which demonstrate the role that the metabolism-acetylation axis has in coordinating the responses of innate immune cells to the availability of nutrients and the microenvironment.

Details

show
hide
Language(s): eng - English
 Dates: 2016-10-28
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.smim.2016.10.003
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Seminars in Immunology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Academic Press
Pages: - Volume / Issue: 28 Sequence Number: - Start / End Page: 408 - 416 Identifier: ISSN: 1044-5323
CoNE: https://pure.mpg.de/cone/journals/resource/954922650149