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  Automated glycan assembly in a variable-bed flow reactor provides insights into oligosaccharide–resin interactions

Sletten, E. T., Danglad-Flores, J. A., Nuño, M., Guthrie, D., & Seeberger, P. H. (2020). Automated glycan assembly in a variable-bed flow reactor provides insights into oligosaccharide–resin interactions. Organic Letters, 22(11), 4213-4216. doi:10.1021/acs.orglett.0c01264.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-6C71-2 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8A9E-D
Genre: Journal Article

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 Creators:
Sletten, Eric T.1, Author              
Danglad-Flores, José Angél1, Author              
Nuño, Manuel, Author
Guthrie, Duncan, Author
Seeberger, Peter H.1, Author              
Affiliations:
1Peter H. Seeberger - Automated Systems, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863306              

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Free keywords: Peptides and proteins; Organic polymers; Oligosaccharides; Solvation; Solvents
 Abstract: A pressure-based variable-bed flow reactor built for peptide synthesis and capable of real-time monitoring of resin swelling was adapted for automated glycan assembly. In the context of the solid-phase synthesis of several oligosaccharides, the coupling efficiencies, resin growth patterns, and saccharide solvation during the synthesis were determined. The presented work provides the first estimation of on-resin oligosaccharide solvation and an alternative technique to UV–vis monitoring.

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Language(s): eng - English
 Dates: 2020-05-122020
 Publication Status: Published in print
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 Identifiers: DOI: 10.1021/acs.orglett.0c01264
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Title: Organic Letters
  Other : Org. Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 22 (11) Sequence Number: - Start / End Page: 4213 - 4216 Identifier: ISSN: 1523-7060