Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Inert macrocyclic Eu3+ complex with affirmative paraCEST features

Gambino, T., Valencia, L., Pérez-Lourido, P., Esteban-Gómez, D., Zaiss, M., Platas-Iglesias, C., et al. (2020). Inert macrocyclic Eu3+ complex with affirmative paraCEST features. Inorganic Chemistry Frontiers, 7(12), 2274-2286. doi:10.1039/c9qi01612k.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Gambino, T1, 2, Autor           
Valencia, L, Autor
Pérez-Lourido, P, Autor
Esteban-Gómez, D, Autor
Zaiss, M2, 3, Autor           
Platas-Iglesias, C, Autor
Angelovski, G1, 2, Autor           
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

Inhalt

einblenden:
ausblenden:
Schlagwörter: -
 Zusammenfassung: We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST (paramagnetic chemical exchange saturation transfer) contrast agents. The investigated europium(III) chelate is non-hydrated and contains four amide groups, each possessing two paramagnetically shifted proton resonances distant from bulk water. The X-ray crystal structure and solution studies indicate that the metal ion is ten-coordinated, being directly bound to the six N atoms of the macrocycle and the four amide O atoms of the pendant arms. The complex presents an excellent inertness with respect to dissociation, being stable under a variety of harsh conditions, including highly acidic and basic media or elevated temperatures. The amide protons are in slow-to-intermediate exchange with bulk water, which gives rise to the generation of a strong CEST effect at low probe concentration and saturation powers (∼25% at 5 mM, B1 = 5 μT, 37 °C). We demonstrate the potential of this platform for mapping pH in its microenvironment and foresee potential for the development of diverse paraCEST probes and sensors.

Details

einblenden:
ausblenden:
Sprache(n):
 Datum: 2020-032020-06
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1039/c9qi01612k
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Inorganic Chemistry Frontiers
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Cambridge, England : RSC
Seiten: - Band / Heft: 7 (12) Artikelnummer: - Start- / Endseite: 2274 - 2286 Identifikator: ISSN: 2052-1553
CoNE: https://pure.mpg.de/cone/journals/resource/2052-1553