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  Variability in the analysis of a single neuroimaging dataset by many teams

Botvinik-Nezer, R., Holzmeister, F., Camerer, C. F., Dreber, A., Huber, J., Johannesson, M., et al. (2020). Variability in the analysis of a single neuroimaging dataset by many teams. Nature, 582, 84-88. doi:10.1038/s41586-020-2314-9.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-715A-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8EFA-1
Genre: Journal Article

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 Creators:
Botvinik-Nezer, Rotem, Author
Holzmeister, Felix, Author
Camerer, Colin F., Author
Dreber, Anna, Author
Huber, Juergen, Author
Johannesson, Magnus, Author
Kirchler, Michael, Author
Iwanir, Roni, Author
Mumford, Jeanette A., Author
Adcock, R. Alison, Author
Avesani, Paolo, Author
Baczkowski, Blazej1, Author              
Bajracharya, Aahana, Author
Bakst, Leah, Author
Ball, Sheryl, Author
Barilari, Marco, Author
Bault, Nadège, Author
Beaton, Derek, Author
Beitner, Julia, Author
Benoit, Roland G.2, Author              
Berkers, Ruud2, Author              Bhanji, Jamil P., AuthorBiswal, Bharat B., AuthorBobadilla-Suarez, Sebastian, AuthorBortolini, Tiago, AuthorBottenhorn, Katherine L., AuthorBowring, Alexander, AuthorBraem, Senne, AuthorBrooks, Hayley R., AuthorBrudner, Emily G., AuthorCalderon, Cristian B., AuthorCamilleri, Julia A., AuthorCastrellon, Jaime J., AuthorCecchetti, Luca, AuthorCieslik, Edna C., AuthorCole, Zachary J., AuthorCollignon, Olivier, AuthorCox, Robert W., AuthorCunningham, William A., AuthorCzoschke, Stefan, AuthorDadi, Kamalaker, AuthorDavis, Charles P., AuthorLuca, Alberto De, AuthorDelgado, Mauricio R., AuthorDemetriou, Lysia, AuthorDennison, Jeffrey B., AuthorDi, Xin, AuthorDickie, Erin W., AuthorDobryakova, Ekaterina, AuthorDonnat, Claire L., AuthorDukart, Juergen, AuthorDuncan, Niall W., AuthorDurnez, Joke, AuthorEed, Amr, AuthorEickhoff, Simon B., AuthorErhart, Andrew, AuthorFontanesi, Laura, AuthorFricke, G. Matthew, AuthorFu, Shiguang, AuthorGalván, Adriana, AuthorGau, Remi, AuthorGenon, Sarah, AuthorGlatard, Tristan, AuthorGlerean, Enrico, AuthorGoeman, Jelle J., AuthorGolowin, Sergej A. E., AuthorGonzález-García, Carlos, AuthorGorgolewski, Krzysztof J., AuthorGrady, Cheryl L., AuthorGreen, Mikella A., AuthorMoreira, João F. Guassi, AuthorGuest, Olivia, AuthorHakimi, Shabnam, AuthorHamilton, J. Paul, AuthorHancock, Roeland, AuthorHandjaras, Giacomo, AuthorHarry, Bronson B., AuthorHawco, Colin, AuthorHerholz, Peer, AuthorHerman, Gabrielle, AuthorHeunis, Stephan, AuthorHoffstaedter, Felix, AuthorHogeveen, Jeremy, AuthorHolmes, Susan, AuthorHu, Chuan-Peng, AuthorHuettel, Scott A., AuthorHughes, Matthew E., AuthorIacovella, Vittorio, AuthorIordan, Alexandru D., AuthorIsager, Peder M., AuthorIsik, Ayse I., AuthorJahn, Andrew, AuthorJohnson, Matthew R., AuthorJohnstone, Tom, AuthorJoseph, Michael J. E., AuthorJuliano, Anthony C., AuthorKable, Joseph W., AuthorKassinopoulos, Michalis, AuthorKoba, Cemal, AuthorKong, Xiang-Zhen, AuthorKoscik, Timothy R., AuthorKucukboyaci, Nuri Erkut, AuthorKuhl, Brice A., AuthorKupek, Sebastian, AuthorLaird, Angela R., AuthorLamm, Claus, AuthorLangner, Robert, AuthorLauharatanahirun, Nina, AuthorLee, Hongmi, AuthorLee, Sangil, AuthorLeemans, Alexander, AuthorLeo, Andrea, AuthorLesage, Elise, AuthorLi, Flora, AuthorLi, Monica Y. C., AuthorLim, Phui Cheng, AuthorLintz, Evan N., AuthorLiphardt, Schuyler W., AuthorVermeer, Annabel B. Losecaat, AuthorLove, Bradley C., AuthorMack, Michael L., AuthorMalpica, Norberto, AuthorMarins, Theo, AuthorMaumet, Camille, AuthorMcDonald, Kelsey, AuthorMcGuire, Joseph T., AuthorMelero, Helena, AuthorLeal, Adriana S. Méndez, AuthorMeyer, Benjamin, AuthorMeyer, Kristin N., AuthorMihai, Paul Glad3, Author              Mitsis, Georgios D., AuthorMoll, Jorge, AuthorNielson, Dylan M., AuthorNilsonne, Gustav, AuthorNotter, Michael P., AuthorOlivetti, Emanuele, AuthorOnicas, Adrian I., AuthorPapale, Paolo, AuthorPatil, Kaustubh R., AuthorPeelle, Jonathan E., AuthorPérez, Alexandre, AuthorPischedda, Doris, AuthorPoline, Jean-Baptiste, AuthorPrystauka, Yanina, AuthorRay, Shruti, AuthorReuter-Lorenz, Patricia A., AuthorReynolds, Richard C., AuthorRicciardi, Emiliano, AuthorRieck, Jenny R., AuthorRodriguez-Thompson, Anais M., AuthorRomyn, Anthony, AuthorSalo, Taylor, AuthorSamanez-Larkin, Gregory R., AuthorSanz-Morales, Emilio, AuthorSchlichting, Margaret L., AuthorSchultz, Douglas H., AuthorShen, Qiang, AuthorSheridan, Margaret A., AuthorSilvers, Jennifer A., AuthorSkagerlund, Kenny, AuthorSmith, Alec, AuthorSmith, David V., AuthorSokol-Hessner, Peter, AuthorSteinkamp, Simon R., AuthorTashjian, Sarah M., AuthorThirion, Bertrand, AuthorThorp, John N., AuthorTinghög, Gustav, AuthorTisdall, Loreen, AuthorTompson, Steven H., AuthorToro-Serey, Claudio, AuthorTresols, Juan Jesus Torre, AuthorTozzi, Leonardo, AuthorTruong, Vuong, AuthorTurella, Luca, Authorvan Veer, Anna E. ‘t, AuthorVerguts, Tom, AuthorVettel, Jean M., AuthorVijayarajah, Sagana, AuthorVo, Khoi, AuthorWall, Matthew B., AuthorWeeda, Wouter D., AuthorWeis, Susanne, AuthorWhite, David J., AuthorWisniewski, David, AuthorXifra-Porxas, Alba, AuthorYearling, Emily A., AuthorYoon, Sangsuk, AuthorYuan, Rui, AuthorYuen, Kenneth S. L., AuthorZhang, Lei, AuthorZhang, Xu, AuthorZosky, Joshua E., AuthorNichols, Thomas E., AuthorPoldrack, Russell A., AuthorSchonberg, Tom, Author more..
Affiliations:
1International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2616696              
2Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691              
3Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556              

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Free keywords: Decision; Decision making; Human behaviour; Scientific community
 Abstract: Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses1. The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset2,3,4,5. Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed.

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Language(s): eng - English
 Dates: 2019-11-142020-04-072020-05-202020-06-04
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1038/s41586-020-2314-9
Other: epub 2020
PMID: 32483374
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 582 Sequence Number: - Start / End Page: 84 - 88 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238