Variability in the analysis of a single neuroimaging dataset by many teams

Botvinik-Nezer, Rotem; Holzmeister, Felix; Camerer, Colin F.; Dreber, Anna; Huber, Juergen; Johannesson, Magnus; Kirchler, Michael; Iwanir, Roni; Mumford, Jeanette A.; Adcock, R. Alison; Avesani, Paolo; Baczkowski, Blazej; Bajracharya, Aahana; Bakst, Leah; Ball, Sheryl; Barilari, Marco; Bault, Nadège; Beaton, Derek; Beitner, Julia; Benoit, Roland G.; Berkers, Ruud; Bhanji, Jamil P.; Biswal, Bharat B.; Bobadilla-Suarez, Sebastian; Bortolini, Tiago; Bottenhorn, Katherine L.; Bowring, Alexander; Braem, Senne; Brooks, Hayley R.; Brudner, Emily G.; Calderon, Cristian B.; Camilleri, Julia A.; Castrellon, Jaime J.; Cecchetti, Luca; Cieslik, Edna C.; Cole, Zachary J.; Collignon, Olivier; Cox, Robert W.; Cunningham, William A.; Czoschke, Stefan; Dadi, Kamalaker; Davis, Charles P.; Luca, Alberto De; Delgado, Mauricio R.; Demetriou, Lysia; Dennison, Jeffrey B.; Di, Xin; Dickie, Erin W.; Dobryakova, Ekaterina; Donnat, Claire L.; Dukart, Juergen; Duncan, Niall W.; Durnez, Joke; Eed, Amr; Eickhoff, Simon B.; Erhart, Andrew; Fontanesi, Laura; Fricke, G. Matthew; Fu, Shiguang; Galván, Adriana; Gau, Remi; Genon, Sarah; Glatard, Tristan; Glerean, Enrico; Goeman, Jelle J.; Golowin, Sergej A. E.; González-García, Carlos; Gorgolewski, Krzysztof J.; Grady, Cheryl L.; Green, Mikella A.; Moreira, João F. Guassi; Guest, Olivia; Hakimi, Shabnam; Hamilton, J. Paul; Hancock, Roeland; Handjaras, Giacomo; Harry, Bronson B.; Hawco, Colin; Herholz, Peer; Herman, Gabrielle; Heunis, Stephan; Hoffstaedter, Felix; Hogeveen, Jeremy; Holmes, Susan; Hu, Chuan-Peng; Huettel, Scott A.; Hughes, Matthew E.; Iacovella, Vittorio; Iordan, Alexandru D.; Isager, Peder M.; Isik, Ayse I.; Jahn, Andrew; Johnson, Matthew R.; Johnstone, Tom; Joseph, Michael J. E.; Juliano, Anthony C.; Kable, Joseph W.; Kassinopoulos, Michalis; Koba, Cemal; Kong, Xiang-Zhen; Koscik, Timothy R.; Kucukboyaci, Nuri Erkut; Kuhl, Brice A.; Kupek, Sebastian; Laird, Angela R.; Lamm, Claus; Langner, Robert; Lauharatanahirun, Nina; Lee, Hongmi; Lee, Sangil; Leemans, Alexander; Leo, Andrea; Lesage, Elise; Li, Flora; Li, Monica Y. C.; Lim, Phui Cheng; Lintz, Evan N.; Liphardt, Schuyler W.; Vermeer, Annabel B. Losecaat; Love, Bradley C.; Mack, Michael L.; Malpica, Norberto; Marins, Theo; Maumet, Camille; McDonald, Kelsey; McGuire, Joseph T.; Melero, Helena; Leal, Adriana S. Méndez; Meyer, Benjamin; Meyer, Kristin N.; Mihai, Paul Glad; Mitsis, Georgios D.; Moll, Jorge; Nielson, Dylan M.; Nilsonne, Gustav; Notter, Michael P.; Olivetti, Emanuele; Onicas, Adrian I.; Papale, Paolo; Patil, Kaustubh R.; Peelle, Jonathan E.; Pérez, Alexandre; Pischedda, Doris; Poline, Jean-Baptiste; Prystauka, Yanina; Ray, Shruti; Reuter-Lorenz, Patricia A.; Reynolds, Richard C.; Ricciardi, Emiliano; Rieck, Jenny R.; Rodriguez-Thompson, Anais M.; Romyn, Anthony; Salo, Taylor; Samanez-Larkin, Gregory R.; Sanz-Morales, Emilio; Schlichting, Margaret L.; Schultz, Douglas H.; Shen, Qiang; Sheridan, Margaret A.; Silvers, Jennifer A.; Skagerlund, Kenny; Smith, Alec; Smith, David V.; Sokol-Hessner, Peter; Steinkamp, Simon R.; Tashjian, Sarah M.; Thirion, Bertrand; Thorp, John N.; Tinghög, Gustav; Tisdall, Loreen; Tompson, Steven H.; Toro-Serey, Claudio; Tresols, Juan Jesus Torre; Tozzi, Leonardo; Truong, Vuong; Turella, Luca; van Veer, Anna E. ‘t; Verguts, Tom; Vettel, Jean M.; Vijayarajah, Sagana; Vo, Khoi; Wall, Matthew B.; Weeda, Wouter D.; Weis, Susanne; White, David J.; Wisniewski, David; Xifra-Porxas, Alba; Yearling, Emily A.; Yoon, Sangsuk; Yuan, Rui; Yuen, Kenneth S. L.; Zhang, Lei; Zhang, Xu; Zosky, Joshua E.; Nichols, Thomas E.; Poldrack, Russell A.; Schonberg, Tom

doi:10.1038/s41586-020-2314-9

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Variability in the analysis of a single neuroimaging dataset by many teams

Botvinik-Nezer, R., Holzmeister, F., Camerer, C. F., Dreber, A., Huber, J., Johannesson, M., et al. (2020). Variability in the analysis of a single neuroimaging dataset by many teams. Nature, 582(7810), 84-88. doi:10.1038/s41586-020-2314-9.

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Botvinik-Nezer, Rotem, Autor
Holzmeister, Felix, Autor
Camerer, Colin F., Autor
Dreber, Anna, Autor
Huber, Juergen, Autor
Johannesson, Magnus, Autor
Kirchler, Michael, Autor
Iwanir, Roni, Autor
Mumford, Jeanette A., Autor
Adcock, R. Alison, Autor
Avesani, Paolo, Autor
Baczkowski, Blazej¹, Autor
Bajracharya, Aahana, Autor
Bakst, Leah, Autor
Ball, Sheryl, Autor
Barilari, Marco, Autor
Bault, Nadège, Autor
Beaton, Derek, Autor
Beitner, Julia, Autor
Benoit, Roland G.², Autor
Berkers, Ruud², Autor         Bhanji, Jamil P., AutorBiswal, Bharat B., AutorBobadilla-Suarez, Sebastian, AutorBortolini, Tiago, AutorBottenhorn, Katherine L., AutorBowring, Alexander, AutorBraem, Senne, AutorBrooks, Hayley R., AutorBrudner, Emily G., AutorCalderon, Cristian B., AutorCamilleri, Julia A., AutorCastrellon, Jaime J., AutorCecchetti, Luca, AutorCieslik, Edna C., AutorCole, Zachary J., AutorCollignon, Olivier, AutorCox, Robert W., AutorCunningham, William A., AutorCzoschke, Stefan, AutorDadi, Kamalaker, AutorDavis, Charles P., AutorLuca, Alberto De, AutorDelgado, Mauricio R., AutorDemetriou, Lysia, AutorDennison, Jeffrey B., AutorDi, Xin, AutorDickie, Erin W., AutorDobryakova, Ekaterina, AutorDonnat, Claire L., AutorDukart, Juergen, AutorDuncan, Niall W., AutorDurnez, Joke, AutorEed, Amr, AutorEickhoff, Simon B., AutorErhart, Andrew, AutorFontanesi, Laura, AutorFricke, G. Matthew, AutorFu, Shiguang, AutorGalván, Adriana, AutorGau, Remi, AutorGenon, Sarah, AutorGlatard, Tristan, AutorGlerean, Enrico, AutorGoeman, Jelle J., AutorGolowin, Sergej A. E., AutorGonzález-García, Carlos, AutorGorgolewski, Krzysztof J., AutorGrady, Cheryl L., AutorGreen, Mikella A., AutorMoreira, João F. Guassi, AutorGuest, Olivia, AutorHakimi, Shabnam, AutorHamilton, J. Paul, AutorHancock, Roeland, AutorHandjaras, Giacomo, AutorHarry, Bronson B., AutorHawco, Colin, AutorHerholz, Peer, AutorHerman, Gabrielle, AutorHeunis, Stephan, AutorHoffstaedter, Felix, AutorHogeveen, Jeremy, AutorHolmes, Susan, AutorHu, Chuan-Peng, AutorHuettel, Scott A., AutorHughes, Matthew E., AutorIacovella, Vittorio, AutorIordan, Alexandru D., AutorIsager, Peder M., AutorIsik, Ayse I., AutorJahn, Andrew, AutorJohnson, Matthew R., AutorJohnstone, Tom, AutorJoseph, Michael J. E., AutorJuliano, Anthony C., AutorKable, Joseph W., AutorKassinopoulos, Michalis, AutorKoba, Cemal, AutorKong, Xiang-Zhen, AutorKoscik, Timothy R., AutorKucukboyaci, Nuri Erkut, AutorKuhl, Brice A., AutorKupek, Sebastian, AutorLaird, Angela R., AutorLamm, Claus, AutorLangner, Robert, AutorLauharatanahirun, Nina, AutorLee, Hongmi, AutorLee, Sangil, AutorLeemans, Alexander, AutorLeo, Andrea, AutorLesage, Elise, AutorLi, Flora, AutorLi, Monica Y. C., AutorLim, Phui Cheng, AutorLintz, Evan N., AutorLiphardt, Schuyler W., AutorVermeer, Annabel B. Losecaat, AutorLove, Bradley C., AutorMack, Michael L., AutorMalpica, Norberto, AutorMarins, Theo, AutorMaumet, Camille, AutorMcDonald, Kelsey, AutorMcGuire, Joseph T., AutorMelero, Helena, AutorLeal, Adriana S. Méndez, AutorMeyer, Benjamin, AutorMeyer, Kristin N., AutorMihai, Paul Glad³, Autor         Mitsis, Georgios D., AutorMoll, Jorge, AutorNielson, Dylan M., AutorNilsonne, Gustav, AutorNotter, Michael P., AutorOlivetti, Emanuele, AutorOnicas, Adrian I., AutorPapale, Paolo, AutorPatil, Kaustubh R., AutorPeelle, Jonathan E., AutorPérez, Alexandre, AutorPischedda, Doris, AutorPoline, Jean-Baptiste, AutorPrystauka, Yanina, AutorRay, Shruti, AutorReuter-Lorenz, Patricia A., AutorReynolds, Richard C., AutorRicciardi, Emiliano, AutorRieck, Jenny R., AutorRodriguez-Thompson, Anais M., AutorRomyn, Anthony, AutorSalo, Taylor, AutorSamanez-Larkin, Gregory R., AutorSanz-Morales, Emilio, AutorSchlichting, Margaret L., AutorSchultz, Douglas H., AutorShen, Qiang, AutorSheridan, Margaret A., AutorSilvers, Jennifer A., AutorSkagerlund, Kenny, AutorSmith, Alec, AutorSmith, David V., AutorSokol-Hessner, Peter, AutorSteinkamp, Simon R., AutorTashjian, Sarah M., AutorThirion, Bertrand, AutorThorp, John N., AutorTinghög, Gustav, AutorTisdall, Loreen, AutorTompson, Steven H., AutorToro-Serey, Claudio, AutorTresols, Juan Jesus Torre, AutorTozzi, Leonardo, AutorTruong, Vuong, AutorTurella, Luca, Autorvan Veer, Anna E. ‘t, AutorVerguts, Tom, AutorVettel, Jean M., AutorVijayarajah, Sagana, AutorVo, Khoi, AutorWall, Matthew B., AutorWeeda, Wouter D., AutorWeis, Susanne, AutorWhite, David J., AutorWisniewski, David, AutorXifra-Porxas, Alba, AutorYearling, Emily A., AutorYoon, Sangsuk, AutorYuan, Rui, AutorYuen, Kenneth S. L., AutorZhang, Lei, AutorZhang, Xu, AutorZosky, Joshua E., AutorNichols, Thomas E., AutorPoldrack, Russell A., AutorSchonberg, Tom, Autor mehr..

Affiliations:
1International Max Planck Research School on Neuroscience of Communication: Function, Structure, and Plasticity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2616696
2Max Planck Research Group Adaptive Memory, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2295691
3Max Planck Research Group Neural Mechanisms of Human Communication, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634556

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Schlagwörter: Decision; Decision making; Human behaviour; Scientific community

Zusammenfassung: Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses1. The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset2,3,4,5. Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed.

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Sprache(n): eng - English

Datum: Eingereicht: 2019-11-14Angenommen: 2020-04-07Online veröffentlicht: 2020-05-20Erschienen: 2020-06-04

Publikationsstatus: Erschienen

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Identifikatoren: DOI: 10.1038/s41586-020-2314-9
Anderer: epub 2020
PMID: 32483374

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Förderorganisation : Tianqiao and Chrissy Center for Social and Decision Neuroscience Center Leadership Chair

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Titel: Nature

Kurztitel : Nature

Genre der Quelle: Zeitschrift

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Ort, Verlag, Ausgabe: London : Nature Publishing Group

Seiten: - Band / Heft: 582 (7810) Artikelnummer: - Start- / Endseite: 84 - 88 Identifikator: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238

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