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  STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer

Oberhuber, M., Pecoraro, M., Rusz, M., Oberhuber, G., Wieselberg, M., Haslinger, P., et al. (2020). STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer. MOLECULAR SYSTEMS BIOLOGY, 16(4): e9247. doi:10.15252/msb.20199247.

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 Creators:
Oberhuber, Monika1, Author
Pecoraro, Matteo2, Author              
Rusz, Mate1, Author
Oberhuber, Georg1, Author
Wieselberg, Maritta1, Author
Haslinger, Peter1, Author
Gurnhofer, Elisabeth1, Author
Schlederer, Michaela1, Author
Limberger, Tanja1, Author
Lagger, Sabine1, Author
Pencik, Jan1, Author
Kodajova, Petra1, Author
Högler, Sandra1, Author
Stockmaier, Georg1, Author
Grund-Gröschke, Sandra1, Author
Aberger, Fritz1, Author
Bolis, Marco1, Author
Theurillat, Jean-Philippe1, Author
Wiebringhaus, Robert1, Author
Weiss, Theresa1, Author
Haitel, Andrea1, AuthorBrehme, Marc1, AuthorWadsak, Wolfgang1, AuthorGriss, Johannes1, AuthorMohr, Thomas1, AuthorHofer, Alexandra1, AuthorJäger, Anton1, AuthorPollheimer, Juergen1, AuthorEgger, Gerda1, AuthorKoellensperger, Gunda1, AuthorMann, Matthias2, Author              Hantusch, Brigitte1, AuthorKenner, Lukas1, Author more..
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: DIFFERENTIAL EXPRESSION ANALYSIS; COMPUTATIONAL PLATFORM; GENE ONTOLOGY; DNA ELEMENTS; TARGET GENES; ACID CYCLE; STAT3; METABOLISM; GENOME; ENCYCLOPEDIAOXPHOS; PDK4; prostate cancer; STAT3; TCA cycle;
 Abstract: Prostate cancer (PCa) has a broad spectrum of clinical behavior; hence, biomarkers are urgently needed for risk stratification. Here, we aim to find potential biomarkers for risk stratification, by utilizing a gene co-expression network of transcriptomics data in addition to laser-microdissected proteomics from human and murine prostate FFPE samples. We show up-regulation of oxidative phosphorylation (OXPHOS) in PCa on the transcriptomic level and up-regulation of the TCA cycle/OXPHOS on the proteomic level, which is inversely correlated to STAT3 expression. We hereby identify gene expression of pyruvate dehydrogenase kinase 4 (PDK4), a key regulator of the TCA cycle, as a promising independent prognostic marker in PCa. PDK4 predicts disease recurrence independent of diagnostic risk factors such as grading, staging, and PSA level. Therefore, low PDK4 is a promising marker for PCa with dismal prognosis.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 27
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000530421100004
DOI: 10.15252/msb.20199247
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Title: MOLECULAR SYSTEMS BIOLOGY
Source Genre: Journal
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Publ. Info: 111 RIVER ST, HOBOKEN 07030-5774, NJ USA : WILEY
Pages: - Volume / Issue: 16 (4) Sequence Number: e9247 Start / End Page: - Identifier: ISSN: 1744-4292