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  The effect of scan length on the assessment of BOLD delay in ischemic stroke

Tanrıtanır, A. C., Villringer, K., Galinovic, I., Grittner, U., Kirilina, E., Fiebach, J. B., et al. (2020). The effect of scan length on the assessment of BOLD delay in ischemic stroke. Frontiers in Neurology, 11: 381. doi:10.3389/fneur.2020.00381.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-7839-4 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-783A-3
Genre: Journal Article

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Tanrıtanır, Ayse Ceren1, Author
Villringer, Kersten1, Author
Galinovic, Ivana1, Author
Grittner, Ulrike2, 3, Author
Kirilina, Evgeniya4, 5, Author              
Fiebach, Jochen B.1, Author
Villringer, Arno6, 7, Author              
Khalil, Ahmed1, 3, 6, 7, Author              
Affiliations:
1Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Biostatistics and Clinical Epidemiology, Charité University Medicine Berlin, Germany, ou_persistent22              
3Berlin Institute of Health (BIH), Germany, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
5Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
6Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
7Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              

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Free keywords: Perfusion; Acute stroke; BOLD delay; Scan length; MRI
 Abstract: Objectives: To evaluate the impact of resting-state functional MRI scan length on the diagnostic accuracy, image quality and lesion volume estimation of BOLD delay maps used for brain perfusion assessment in acute ischemic stroke. Methods: Sixty-three acute ischemic stroke patients received a 340 s resting-state functional MRI within 24 h of stroke symptom onset. BOLD delay maps were calculated from the full scan and four shortened versions (68 s, 136 s, 204 s, 272 s). The BOLD delay lesions on these maps were compared in terms of spatial overlap and volumetric agreement with the lesions derived from the full scans and with time-to-maximum (Tmax) lesions derived from DSC-MRI in a subset of patients (n = 10). In addition, the interpretability and quality of these maps were compared across different scan lengths using mixed models. Results: Shortened BOLD delay scans showed a small volumetric bias (ranging from 0.05 to 5.3 mL; between a 0.13% volumetric underestimation and a 7.7% overestimation relative to the mean of the volumes, depending on scan length) compared to the full scan. Decreased scan length was associated with decreased spatial overlap with both the BOLD delay lesions derived from the full scans and with Tmax lesions. Only the two shortest scan lengths (68 and 136 s) were associated with substantially decreased interpretability, decreased structure clarity, and increased noisiness of BOLD delay maps. Conclusions: BOLD delay maps derived from resting-state fMRI scans lasting 272 and 204 s provide sufficient diagnostic quality and adequate assessment of perfusion lesion volumes. Such shortened scans may be helpful in situations where quick clinical decisions need to be made.

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Language(s): eng - English
 Dates: 2019-12-052020-04-152020-05-05
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.3389/fneur.2020.00381
Other: eCollection 2020
PMID: 32431665
PMC: PMC7214917
 Degree: -

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Title: Frontiers in Neurology
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 381 Start / End Page: - Identifier: ISSN: 1664-2295
CoNE: https://pure.mpg.de/cone/journals/resource/1664-2295