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  Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis.

Witte, M. E., Schumacher, A.-M., Mahler, C. F., Bewersdorf, J., Lehmitz, J., Scheiter, A., et al. (2019). Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron, 101(4), 615-624. doi:10.1016/j.neuron.2018.12.023.

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 Creators:
Witte, Maarten E, Author
Schumacher, Adrian-Minh, Author
Mahler, Christoph F, Author
Bewersdorf, Joerg, Author
Lehmitz, Jonas, Author
Scheiter, Alexander, Author
Sánchez, Paula, Author
Williams, Philip R, Author
Griesbeck, Oliver, Author
Naumann, Ronald1, Author           
Misgeld, Thomas, Author
Kerschensteiner, Martin, Author
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: Axon loss determines persistent disability in multiple sclerosis patients. Here, we use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. We rule out the endoplasmic reticulum, glutamate excitotoxicity, and the reversal of the sodium-calcium exchanger as sources of intra-axonal calcium accumulation and instead identify nanoscale ruptures of the axonal plasma membrane as the critical path of calcium entry.

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 Dates: 2019-02-20
 Publication Status: Issued
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuron.2018.12.023
Other: cbg-7319
PMID: 30686733
 Degree: -

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Title: Neuron
  Other : Neuron
Source Genre: Journal
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Pages: - Volume / Issue: 101 (4) Sequence Number: - Start / End Page: 615 - 624 Identifier: -