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  Proteome-wide signatures of function in highly diverged intrinsically disordered regions.

Zarin, T., Strome, B., Ba, A. N. N., Alberti, S., Forman-Kay, J. D., & Moses, A. M. (2019). Proteome-wide signatures of function in highly diverged intrinsically disordered regions. eLife, 8: e46883. doi:10.7554/eLife.46883.

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 Creators:
Zarin, Taraneh, Author
Strome, Bob, Author
Ba, Alex N Nguyen, Author
Alberti, Simon1, Author           
Forman-Kay, Julie D, Author
Moses, Alan M, Author
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignments. Here we use an evolutionary approach to detect molecular features that are preserved in the amino acid sequences of orthologous intrinsically disordered regions. We find that most disordered regions contain multiple molecular features that are preserved, and we define these as 'evolutionary signatures' of disordered regions. We demonstrate that intrinsically disordered regions with similar evolutionary signatures can rescue function in vivo, and that groups of intrinsically disordered regions with similar evolutionary signatures are strongly enriched for functional annotations and phenotypes. We propose that evolutionary signatures can be used to predict function for many disordered regions from their amino acid sequences.

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 Dates: 2019-07-02
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.7554/eLife.46883
Other: cbg-7435
PMID: 31264965
 Degree: -

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Title: eLife
  Other : Elife
Source Genre: Journal
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Pages: - Volume / Issue: 8 Sequence Number: e46883 Start / End Page: - Identifier: -