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  The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Ortega, G. C., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., et al. (2019). The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature, 567(7746), 113-117. doi:10.1038/s41586-019-0962-4.

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 Creators:
Ortega, Germán Camargo, Author
Falk, Sven, Author
Johansson, Pia A, Author
Peyre, Elise, Author
Broix, Loïc, Author
Sahu, Sanjeeb Kumar, Author
Hirst, William, Author
Schlichthaerle, Thomas, Author
Romero, Camino De Juan, Author
Draganova, Kalina, Author
Vinopal, Stanislav, Author
Chinnappa, Kaviya, Author
Gavranovic, Anna, Author
Karakaya, Tugay, Author
Steininger, Thomas, Author
Merl-Pham, Juliane, Author
Feederle, Regina, Author
Shao, Wei, Author
Shi, Song-Hai, Author
Hauck, Stefanie M, Author
Jungmann, Ralf, AuthorBradke, Frank, AuthorBorrell, Víctor, AuthorGeerlof, Arie, AuthorReber, Simone1, Author           Tiwari, Vijay K, AuthorHuttner, Wieland1, Author           Wilsch-Bräuninger, Michaela1, Author           Nguyen, Laurent, AuthorGötz, Magdalena, Author more..
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Abstract: The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination.

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 Dates: 2019-03-01
 Publication Status: Issued
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 Rev. Type: -
 Identifiers: DOI: 10.1038/s41586-019-0962-4
Other: cbg-7349
PMID: 30787442
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Title: Nature
  Other : Nature
Source Genre: Journal
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Pages: - Volume / Issue: 567 (7746) Sequence Number: - Start / End Page: 113 - 117 Identifier: -