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  The centrosome protein AKNA regulates neurogenesis via microtubule organization.

Ortega, G. C., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., et al. (2019). The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature, 567(7746), 113-117. doi:10.1038/s41586-019-0962-4.

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Ortega, Germán Camargo, Autor
Falk, Sven, Autor
Johansson, Pia A, Autor
Peyre, Elise, Autor
Broix, Loïc, Autor
Sahu, Sanjeeb Kumar, Autor
Hirst, William, Autor
Schlichthaerle, Thomas, Autor
Romero, Camino De Juan, Autor
Draganova, Kalina, Autor
Vinopal, Stanislav, Autor
Chinnappa, Kaviya, Autor
Gavranovic, Anna, Autor
Karakaya, Tugay, Autor
Steininger, Thomas, Autor
Merl-Pham, Juliane, Autor
Feederle, Regina, Autor
Shao, Wei, Autor
Shi, Song-Hai, Autor
Hauck, Stefanie M, Autor
Jungmann, Ralf, AutorBradke, Frank, AutorBorrell, Víctor, AutorGeerlof, Arie, AutorReber, Simone1, Autor           Tiwari, Vijay K, AutorHuttner, Wieland1, Autor           Wilsch-Bräuninger, Michaela1, Autor           Nguyen, Laurent, AutorGötz, Magdalena, Autor mehr..
Affiliations:
1Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society, ou_2340692              

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 Zusammenfassung: The expansion of brain size is accompanied by a relative enlargement of the subventricular zone during development. Epithelial-like neural stem cells divide in the ventricular zone at the ventricles of the embryonic brain, self-renew and generate basal progenitors1 that delaminate and settle in the subventricular zone in enlarged brain regions2. The length of time that cells stay in the subventricular zone is essential for controlling further amplification and fate determination. Here we show that the interphase centrosome protein AKNA has a key role in this process. AKNA localizes at the subdistal appendages of the mother centriole in specific subtypes of neural stem cells, and in almost all basal progenitors. This protein is necessary and sufficient to organize centrosomal microtubules, and promote their nucleation and growth. These features of AKNA are important for mediating the delamination process in the formation of the subventricular zone. Moreover, AKNA regulates the exit from the subventricular zone, which reveals the pivotal role of centrosomal microtubule organization in enabling cells to both enter and remain in the subventricular zone. The epithelial-to-mesenchymal transition is also regulated by AKNA in other epithelial cells, demonstrating its general importance for the control of cell delamination.

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 Datum: 2019-03-01
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
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 Identifikatoren: DOI: 10.1038/s41586-019-0962-4
Anderer: cbg-7349
PMID: 30787442
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Titel: Nature
  Andere : Nature
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 567 (7746) Artikelnummer: - Start- / Endseite: 113 - 117 Identifikator: -