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  Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection

Pajkert, A., Ploner, C. J., Lehmann, T.-N., Witte, A. V., Oltmanns, F., Sommer, W., et al. (2020). Early volumetric changes of hippocampus and medial prefrontal cortex following medial temporal lobe resection. European Journal of Neuroscience: European Neuroscience Association. doi:10.1111/ein.14784.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-8114-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8117-E
Genre: Journal Article

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 Creators:
Pajkert, Anna1, Author
Ploner, Christoph J.1, Author
Lehmann, Thomas-Nicolas2, Author
Witte, A. Veronica3, Author              
Oltmanns, Frank4, Author
Sommer, Werner5, Author
Holtkamp, Martin1, 4, Author
Heekeren, Hauke6, 7, Author              
Finke, Carsten1, 8, Author
Affiliations:
1Department of Neurology, Charité University Medicine Berlin, Germany, ou_persistent22              
2Department of Neurosurgery, Helios Clinic, Bad Saarow, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
4Epilepsy-Center Berlin-Brandenburg (EZBB), Germany, ou_persistent22              
5Institute of Psychology, Humboldt University Berlin, Germany, ou_persistent22              
6Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
7Center for Cognitive Neuroscience Berlin (CCNB), FU Berlin, Germany, ou_persistent22              
8Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              

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Free keywords: Default mode network; Hippocampus; Medial prefrontal cortex; Medial temporal lobe resection; Plasticity
 Abstract: Previous studies have shown that cognitive demands and physical exercise stimulate adult neurogenesis in the dentate gyrus and hippocampus. Recent observations in healthy humans and patients with mild cognitive impairment moreover suggest that training-induced increases in hippocampal volume may be associated with improved memory performance. The corresponding plasticity processes in hippocampal volume may occur on timescales of months to years. For patients with focal lesions in this region, previous functional imaging studies suggest that increased recruitment of the contralateral hippocampus and extratemporal regions may be an important part of the reorganization of episodic memory. However, it is currently unclear whether focal damage to the medial temporal lobe (MTL) induces gray matter (GM) volume changes in the intact contralateral hippocampus and in connected network regions on a shorter timescale. We therefore investigated whether unilateral resection of the MTL, including the hippocampus, induces measurable volumetric changes in the contralateral hippocampus and in the default mode network (DMN). We recruited 31 patients with unilateral left (N = 19) or right (N = 12) hippocampal sclerosis undergoing MTL resection for treatment of drug-resistant epilepsy. Structural MRI was acquired immediately before and 3 months after surgery. Longitudinal voxel-based morphometry (VBM) analysis revealed a significant increase of right hippocampal volume following resection of the left anterior MTL. Furthermore, this patient group showed GM volume increases in the DMN. These results demonstrate significant structural plasticity of the contralateral hippocampus, even in patients with a long-standing unilateral hippocampal dysfunction and structural reorganization processes extending to distant, but functionally connected brain regions.

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Language(s): eng - English
 Dates: 2020-05-072020-02-142020-05-092020-05-18
 Publication Status: Published online
 Pages: -
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 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1111/ein.14784
Other: online ahead of print
PMID: 32421911
 Degree: -

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Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988