hide
Free keywords:
-
Abstract:
Collective cell migration plays essential roles in embryogenesis
and also contributes to disease states. Recent years have seen
immense progress in understanding mechanisms and
overarching concepts of collective cell migration.
Self-organization of moving groups emerges as an important
common feature. This includes self-generating gradients,
internal chemotaxis or mechanotaxis and contact-dependent
polarization within migrating cell groups. Here, we will discuss
these concepts and their applications to classical models of
collective cell migration. Further, we discuss new models and
paradigms of collective cell migration and elaborate on open
questions and future challenges. Answering these questions
will help to expand our appreciation of this exciting theme in
developmental cell biology and contribute to the understanding
of disease states.
