English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation

Samata, M., Alexia, A., Richard, G., Georgiev, P., Nuebler, J., Kulkarni, T., et al. (2020). Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell, 182, 127-144. doi:org/10.1016/j.cell.2020.05.026.

Item is

Basic

show hide
Genre: Journal Article

Files

show Files
hide Files
:
Samata et al..pdf (Publisher version), 24MB
 
File Permalink:
-
Name:
Samata et al..pdf
Description:
-
Visibility:
Restricted (Max Planck Institute of Immunobiology and Epigenetics, MFIB; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
cc-by-nc/4.0

Locators

show

Creators

show
hide
 Creators:
Samata, Maria1, Author
Alexia, Anastasios1, Author
Richard, Gautier1, Author
Georgiev, Plamen1, Author              
Nuebler, Johannes2, Author
Kulkarni, Tanvi1, Author
Renschler, Gina Vanessa1, Author              
Basilicata, M. Felicia1, Author              
Zenk, Fides Lea1, Author
Shvedunova, Maria1, Author
Semplicio, Giuseppe1, Author
Mirny, Leonid2, Author
Iovino, Nicola1, Author              
Akhtar, Asifa1, Author              
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243643              
2External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Before zygotic genome activation (ZGA), the quiescent genome undergoes reprogramming to transition into the transcriptionally active state. However, the mechanisms underlying euchromatin establishment during early embryogenesis remain poorly understood. Here, we show that histone H4 lysine 16 acetylation (H4K16ac) is maintained from oocytes to fertilized embryos in Drosophila and mammals. H4K16ac forms large domains that control nucleosome accessibility of promoters prior to ZGA in flies. Maternal depletion of MOF acetyltransferase leading to H4K16ac loss causes aberrant RNA Pol II recruitment, compromises the 3D organization of the active genomic compartments during ZGA, and causes downregulation of postzygotically expressed genes. Germline depletion of histone deacetylases revealed that other acetyl marks cannot compensate for H4K16ac loss in the oocyte. Moreover, zygotic re-expression of MOF was neither able to restore embryonic viability nor onset of X chromosome dosage compensation. Thus, maternal H4K16ac provides an instructive function to the offspring, priming future gene activation.

Details

show
hide
Language(s): eng - English
 Dates: 2020-07-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: org/10.1016/j.cell.2020.05.026
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 182 Sequence Number: - Start / End Page: 127 - 144 Identifier: ISSN: 0092-8674
CoNE: https://pure.mpg.de/cone/journals/resource/954925463183