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Abstract:
Pyramidal tract neurons (PTs) represent the major output cell type of the neocortex. How intracortical activity patterns are transformed into cortical output and whether the output is related to the long-range targets is unknown. We combine injections of mono- and multi-trans-synaptic retrograde tracers with in vivo recordings, morphological reconstructions and computational modelling to assess relationships between the structure, function and subcortical target of identified PTs. We find that disjoint output channels of PTs are able to act in parallel to extract information from sensory stimuli that is most relevant for their respective subcortical targets.
