English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Multiparameter mapping of relaxation (R1 , R2 *), proton density and magnetization transfer saturation at 3 T : A multicenter dual‐vendor reproducibility and repeatability study

Leutritz, T., Seif, M., Helms, G., Samson, R., Curt, A., Freund, P., et al. (2020). Multiparameter mapping of relaxation (R1, R2 *), proton density and magnetization transfer saturation at 3 T: A multicenter dual‐vendor reproducibility and repeatability study. Human Brain Mapping. doi:10.1002/hbm.25122.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-AEEF-A Version Permalink: http://hdl.handle.net/21.11116/0000-0006-AEF4-3
Genre: Journal Article

Files

show Files
hide Files
:
Leutritz_2020.pdf (Publisher version), 4MB
Name:
Leutritz_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Leutritz, Tobias1, Author              
Seif, Maryam1, 2, Author
Helms, Gunther3, Author
Samson, Rebecca4, Author
Curt, Armin2, Author
Freund, Patrick1, 2, 5, 6, Author              
Weiskopf, Nikolaus1, 7, Author              
Affiliations:
1Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
2Balgrist Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Switzerland, ou_persistent22              
3Department of Medical Radiation Physics, Skånes University Hospital, Lund, Sweden, ou_persistent22              
4NMR Research Unit, Queen Square Multiple Sclerosis Centre, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
5Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom, ou_persistent22              
6Department of Brain Repair & Rehabilitation, University College London, United Kingdom, ou_persistent22              
7Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              

Content

show
hide
Free keywords: Multi-parameter mapping (MPM); Quantitative MRI; Multi-center study; Reproducibility; Clinical trial; In-vivo histology using MRI (hMRI)
 Abstract: Multi-center clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multi-parameter mapping (MPM) protocol based on vendor’s product sequences and demonstrate its repeatability and reproducibility for whole-brain coverage. Within approximately 20 minutes, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1] and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI-toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter-site comparability, the intra-site (i.e. scan-rescan experiment) coefficient of variation (CoV), inter-site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra- and inter-site CoV was between 4% and 10% across sites and scan time points for intracranial gray and white matter. A higher intra-site CoV (16%) was observed in R2* maps. The inter-site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multi-center imaging studies targeting microstructural changes, e.g., as a quantitative MRI biomarker for interventional clinical trials.

Details

show
hide
Language(s): eng - English
 Dates: 2020-04-082019-12-162020-06-162020-07-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1002/hbm.25122
Other: online ahead of print
PMID: 32639104
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial / NISCI
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Commission (EC)
Project name : -
Grant ID : 15.0137
Funding program : -
Funding organization : Swiss State Secretariat for Education, Research and Innovation (SERI)
Project name : -
Grant ID : 01EW1711A & B
Funding program : -
Funding organization : Bundesministerium für Bildung und Forschung
Project name : -
Grant ID : INSPIRED
Funding program : -
Funding organization : Craig H. Neilsen Foundation
Project name : -
Grant ID : 32NE30_173678
Funding program : -
Funding organization : ERA‐NET NEURON
Project name : -
Grant ID : IRP‐158
Funding program : -
Funding organization : International Foundation for Research in Paraplegia
Project name : -
Grant ID : INSPIRED
Funding program : -
Funding organization : International Spinal Research Trust
Project name : -
Grant ID : 77/2017, 892/08
Funding program : -
Funding organization : Multiple Sclerosis Society
Project name : -
Grant ID : 181362
Funding program : -
Funding organization : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Project name : -
Grant ID : 616905
Funding program : Seventh Framework Programme
Funding organization : -
Project name : -
Grant ID : NT 2014‐6193
Funding program : -
Funding organization : Vetenskapsrådet
Project name : -
Grant ID : WFL‐CH‐007/14
Funding program : -
Funding organization : Wings for Life

Source 1

show
hide
Title: Human Brain Mapping
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: New York : Wiley-Liss
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 1065-9471
CoNE: https://pure.mpg.de/cone/journals/resource/954925601686