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  Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling

Wieland, T., Nassal, M., Kramer, W., Fricker, G., Bickel, U., & Kurz, G. (1984). Identity of hepatic membrane transport systems for bile salts, phalloidin, and antamanide by photoaffinity labeling. Proceedings of the National Academy of Sciences of the United States of America, 81(16), 5232-5236. doi:10.1073/pnas.81.16.5232.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-8F37-C Version Permalink: http://hdl.handle.net/21.11116/0000-0006-8F38-B
Genre: Journal Article

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 Creators:
Wieland, Theodor1, Author              
Nassal, Michael1, Author              
Kramer, W., Author
Fricker, G., Author
Bickel, U., Author
Kurz, G., Author
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1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              

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 Abstract: Phalloidin, a bicyclic heptapeptide, and antamanide, a monocyclic decapeptide from the poisonous mushroom Amanita phalloides, interact with bile-salt-binding polypeptides of the hepatocyte membrane, as demonstrated by photoaffinity labeling using the photolabile bile salt derivative 7,7,-azo-3 alpha, 12 alpha-dihydroxy-5 beta-cholan-24-oic acid, either unconjugated or taurine conjugated. With the photolabile derivatives of phalloidin, N-delta-(4-[(1-azi-2,2,2-trifluoroethyl) benzoyl]-beta-alanyl)-delta-aminophalloin, (N epsilon-[4-(1-azi-2,2,2-trifluoroethyl)benzoyl]lys6)-anta manide, the same membrane polypeptides with apparent MrS of 54,000 and 48,000 were labeled as with the photolabile derivatives of unconjugated and conjugated bile salts. The presence of bile salts decreased markedly the extent of labeling of these phalloidin- and antamanide-binding polypeptides. These results indicate that hepatic uptake systems for bile salts, phallotoxins, and the cycloamanide antamanide are identical, thus explaining the organotropism of phallotoxins.

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Language(s): eng - English
 Dates: 1984-04-161984-08-01
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
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 Rev. Type: Peer
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 81 (16) Sequence Number: - Start / End Page: 5232 - 5236 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230