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  SERIAL-ORDER recall in working memory across the cognitive spectrum of Parkinson's disease and neuroimaging correlates

Bezdicek, O., Ballarini, T., Albrecht, F., Libon, D. J., Lamar, M., Růžička, F., et al. (2021). SERIAL-ORDER recall in working memory across the cognitive spectrum of Parkinson's disease and neuroimaging correlates. Journal of Neuropsychology, 15(1), 88-111. doi:10.1111/jnp.12208.

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Genre: Zeitschriftenartikel

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 Urheber:
Bezdicek, Ondrej1, Autor
Ballarini, Tommaso2, Autor           
Albrecht, Franziska2, Autor           
Libon, David J.3, Autor
Lamar, Melissa4, Autor
Růžička, Filip1, Autor
Roth, Jan1, Autor
Hurlstone, Mark J.5, Autor
Mueller, Karsten6, 7, Autor           
Schroeter, Matthias L.2, 8, 9, Autor           
Jech, Robert1, Autor
Affiliations:
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Departments of Geriatric, Gerontology, and Psychology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine , Rowan University, Glassboro, NJ, USA, ou_persistent22              
4Department of Psychiatry and Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
5School of Psychology, University of Western Australia, Crawley, Australia, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
8Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
9German Consortium for Frontotemporal Lobar Degeneration (FTLD), Ulm, Germany, ou_persistent22              

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Schlagwörter: Backward Digit Span Task; Parkinson’s disease; SERIAL ORDER; Mild cognitive impairment; Working memory
 Zusammenfassung: We sought to determine if Parkinson's disease (PD) with mild cognitive impairment (MCI) is associated with a greater SERIAL-ORDER (mental manipulation) than ANY-ORDER (auditory span, storage) deficit in working memory (WM). We investigated WM combining neuropsychological measures with the study of brain functional connectivity. A cohort of 160 patients with idiopathic PD, classified as PD-MCI (n = 87) or PD with normal cognition (PD-NC; n = 73), and 70 matched healthy controls were studied. Verbal WM was assessed with the Backward Digit Span Task (BDT; Lamar et al., 2007, Neuropsychologia, 45, 245), measuring SERIAL-ORDER and ANY-ORDER recall. Resting-state MRI data were collected for 15 PD-MCI, 15 PD-NC and 30 controls. Hypothesis-driven seed-based functional connectivity of the dorsolateral prefrontal cortex (DLPFC) was compared between the three groups and correlated with BDT performance. We found the main effect of the test (impairment in SERIAL ORDER > ANY ORDER) and group ((NC = PD-NC) > PD-MCI) in BDT performance that was even more pronounced in SERIAL ORDER when controlling for ANY ORDER variability but not vice versa. Furthermore, PD-MCI compared to other groups were characterized by the functional disconnection between the bilateral DLPFC and the cerebellum. In functional correlations, DLPFC connectivity was positively related to both SERIAL- and ANY-ORDER performance. In conclusion, PD-MCI patients evidenced greater SERIAL-ORDER (manipulation and cognitive control) than ANY-ORDER (storage) working memory impairment than PD-NC and controls with a disrupted DLPFC resting-state connectivity that was also related to the verbal WM performance.

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Sprache(n): eng - English
 Datum: 2019-11-262019-09-032020-05-112021-03
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1111/jnp.12208
Anderer: epub 2020
PMID: 32394540
 Art des Abschluß: -

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Projektinformation

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Projektname : Cognitive Predictors of Neurodegeneration
Grant ID : 16‐01781S
Förderprogramm : -
Förderorganisation : -
Projektname : CLinical IMAging BIological predictors of effects DBS in PD (CLIMABI)
Grant ID : AZV NV19-04-00233
Förderprogramm : -
Förderorganisation : -
Projektname : PROGRES Q27
Grant ID : PROGRES Q27
Förderprogramm : -
Förderorganisation : -
Projektname : -
Grant ID : PDF‐IRG‐1307
Förderprogramm : -
Förderorganisation : Parkinson's Disease Foundation
Projektname : -
Grant ID : MJFF‐11362
Förderprogramm : -
Förderorganisation : Michael J. Fox Foundation
Projektname : -
Grant ID : SCHR 774/5-1
Förderprogramm : -
Förderorganisation : Deutsche Forschungsgemeinschaft (DFG)
Projektname : -
Grant ID : O1GI1007A
Förderprogramm : -
Förderorganisation : German Federal Ministry of Education and Research (BMBF)

Quelle 1

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Titel: Journal of Neuropsychology
  Kurztitel : J Neuropsychol
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: British Psychological Society
Seiten: - Band / Heft: 15 (1) Artikelnummer: - Start- / Endseite: 88 - 111 Identifikator: ISSN: 1748-6645
CoNE: https://pure.mpg.de/cone/journals/resource/1748-6645