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  SERIAL-ORDER recall in working memory across the cognitive spectrum of Parkinson’s disease and neuroimaging correlates

Bezdicek, O., Ballarini, T., Albrecht, F., Libon, D. J., Lamar, M., Růžička, F., et al. (2021). SERIAL-ORDER recall in working memory across the cognitive spectrum of Parkinson’s disease and neuroimaging correlates. Journal of Neuropsychology, 15(1), 88-111. doi:10.1111/jnp.12208.

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Bezdicek, Ondrej1, Author
Ballarini, Tommaso2, Author           
Albrecht, Franziska2, Author           
Libon, David J.3, Author
Lamar, Melissa4, Author
Růžička, Filip1, Author
Roth, Jan1, Author
Hurlstone, Mark J.5, Author
Mueller, Karsten6, 7, Author           
Schroeter, Matthias L.2, 8, 9, Author           
Jech, Robert1, Author
1Department of Neurology, First Faculty of Medicine, Charles University, Prague, Czech Republic, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
3Departments of Geriatric, Gerontology, and Psychology, New Jersey Institute for Successful Aging, School of Osteopathic Medicine , Rowan University, Glassboro, NJ, USA, ou_persistent22              
4Department of Psychiatry and Behavioral Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA, ou_persistent22              
5School of Psychology, University of Western Australia, Crawley, Australia, ou_persistent22              
6Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
7Method and Development Group Neural Data Science and Statistical Computing, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_3282987              
8Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
9German Consortium for Frontotemporal Lobar Degeneration (FTLD), Ulm, Germany, ou_persistent22              


Free keywords: Backward Digit Span Task; Parkinson’s disease; SERIAL ORDER; Mild cognitive impairment; Working memory
 Abstract: We sought to determine if Parkinson's disease (PD) with mild cognitive impairment (MCI) is associated with a greater SERIAL-ORDER (mental manipulation) than ANY-ORDER (auditory span, storage) deficit in working memory (WM). We investigated WM combining neuropsychological measures with the study of brain functional connectivity. A cohort of 160 patients with idiopathic PD, classified as PD-MCI (n = 87) or PD with normal cognition (PD-NC; n = 73), and 70 matched healthy controls were studied. Verbal WM was assessed with the Backward Digit Span Task (BDT; Lamar et al., 2007, Neuropsychologia, 45, 245), measuring SERIAL-ORDER and ANY-ORDER recall. Resting-state MRI data were collected for 15 PD-MCI, 15 PD-NC and 30 controls. Hypothesis-driven seed-based functional connectivity of the dorsolateral prefrontal cortex (DLPFC) was compared between the three groups and correlated with BDT performance. We found the main effect of the test (impairment in SERIAL ORDER > ANY ORDER) and group ((NC = PD-NC) > PD-MCI) in BDT performance that was even more pronounced in SERIAL ORDER when controlling for ANY ORDER variability but not vice versa. Furthermore, PD-MCI compared to other groups were characterized by the functional disconnection between the bilateral DLPFC and the cerebellum. In functional correlations, DLPFC connectivity was positively related to both SERIAL- and ANY-ORDER performance. In conclusion, PD-MCI patients evidenced greater SERIAL-ORDER (manipulation and cognitive control) than ANY-ORDER (storage) working memory impairment than PD-NC and controls with a disrupted DLPFC resting-state connectivity that was also related to the verbal WM performance.


Language(s): eng - English
 Dates: 2019-11-262019-09-032020-05-112021-03
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/jnp.12208
Other: epub 2020
PMID: 32394540
 Degree: -



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Project information

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Project name : Cognitive Predictors of Neurodegeneration
Grant ID : 16‐01781S
Funding program : -
Funding organization : -
Project name : CLinical IMAging BIological predictors of effects DBS in PD (CLIMABI)
Grant ID : AZV NV19-04-00233
Funding program : -
Funding organization : -
Project name : PROGRES Q27
Grant ID : PROGRES Q27
Funding program : -
Funding organization : -
Project name : -
Grant ID : PDF‐IRG‐1307
Funding program : -
Funding organization : Parkinson's Disease Foundation
Project name : -
Grant ID : MJFF‐11362
Funding program : -
Funding organization : Michael J. Fox Foundation
Project name : DFG, SCHR 774/5-1
Grant ID : SCHR 774/5-1
Funding program : -
Funding organization : -
Project name : German Federal Ministry of Education and Research (BMBF) by a grant given to the German FTLD Consortium
Grant ID : FKZ O1GI1007A
Funding program : -
Funding organization : -

Source 1

Title: Journal of Neuropsychology
  Abbreviation : J Neuropsychol
Source Genre: Journal
Publ. Info: British Psychological Society
Pages: - Volume / Issue: 15 (1) Sequence Number: - Start / End Page: 88 - 111 Identifier: ISSN: 1748-6645
CoNE: https://pure.mpg.de/cone/journals/resource/1748-6645