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  A critical review of white matter changes in Huntington’s Disease

Casella, C., Lipp, I., Rosser, A., Jones, D. K., & Metzler-Baddeley, C. (2020). A critical review of white matter changes in Huntington’s Disease. Movement Disorders. doi:10.1002/mds.28109.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-92BF-E Version Permalink: http://hdl.handle.net/21.11116/0000-0006-92C0-B
Genre: Journal Article

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Casella_2020.pdf (Publisher version), 216KB
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 Creators:
Casella, Chiara1, Author
Lipp, Ilona2, Author              
Rosser, Anne3, Author
Jones, Derek K1, 4, Author
Metzler-Baddeley, Claudia1, Author
Affiliations:
1Brain Research Imaging Centre, School of Psychology, Cardiff University, United Kingdom, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3School of Biosciences, Cardiff University, United Kingdom, ou_persistent22              
4Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia, ou_persistent22              

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Free keywords: Huntington’s disease; MRI; Myelin; Oligodendrocytes; White matter microstructure
 Abstract: Huntington’s disease is a genetic neurodegenerative disorder. White matter alterations have recently been identified as a relevant pathophysiological feature of Huntington’s disease, but their etiology and role in disease pathogenesis and progression remain unclear. Increasing evidence suggests that white matter changes in this disorder are attributed to alterations in myelin‐associated biological processes. This review first discusses evidence from neurochemical studies lending support to the demyelination hypothesis of Huntington’s disease, demonstrating aberrant myelination and changes in oligodendrocytes in the Huntington’s brain. Next, evidence from neuroimaging studies is reviewed, the limitations of the described methodologies are discussed, and suggested interpretations of findings from published studies are challenged. Although our understanding of Huntington’s associated pathological changes in the brain will increasingly rely on neuroimaging techniques, the shortcomings of these methodologies must not be forgotten. Advances in magnetic resonance imaging techniques and tissue modeling will enable a better in vivo, longitudinal characterization of the biological properties of white matter microstructure. This in turn will facilitate identification of disease‐related biomarkers and the specification of outcome measures in clinical trials. © 2020 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Language(s): eng - English
 Dates: 2020-04-072020-03-032020-04-302020-06-15
 Publication Status: Published online
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 Identifiers: DOI: 10.1002/mds.28109
Other: online ahead of print
PMID: 32537844
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Title: Movement Disorders
Source Genre: Journal
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Pages: - Volume / Issue: - Sequence Number: - Start / End Page: - Identifier: ISSN: 0885-3185
CoNE: https://pure.mpg.de/cone/journals/resource/954925551353