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  alpha-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity

Altstätter, J., Hess, M. W., Costell, M., & Montanez, E. (2020). alpha-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity. PLOS ONE, 15(3): e0230380. doi:10.1371/journal.pone.0230380.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-92A9-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-92AA-5
Genre: Journal Article

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 Creators:
Altstätter, Johannes1, Author              
Hess, Michael W.2, Author
Costell, Mercedes2, Author
Montanez, Eloi2, Author
Affiliations:
1Fässler, Reinhard / Molecular Medicine, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565147              
2external, ou_persistent22              

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Free keywords: INTEGRIN-LINKED KINASE; SKIN; BETA-1-INTEGRIN
 Abstract: Epidermal morphogenesis and hair follicle (HF) development depend on the ability of keratinocytes to adhere to the basement membrane (BM) and migrate along the extracellular matrix. Integrins are cell-matrix receptors that control keratinocyte adhesion and migration, and are recognized as major regulators of epidermal homeostasis. How integrins regulate the behavior of keratinocytes during epidermal morphogenesis remains insufficiently understood. Here, we show that alpha-parvin (alpha-pv), a focal adhesion protein that couples integrins to actin cytoskeleton, is indispensable for epidermal morphogenesis and HF development. Inactivation of the murine alpha-pv gene in basal keratinocytes results in keratinocyte-BM detachment, epidermal thickening, ectopic keratinocyte proliferation and altered actin cytoskeleton polarization. In vitro, alpha-pv-null keratinocytes display reduced adhesion to BM matrix components, aberrant spreading and stress fibers formation, and impaired directed migration. Together, our data demonstrate that alpha-pv controls epidermal homeostasis by facilitating integrin-mediated adhesion and actin cytoskeleton organization in keratinocytes.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: PLOS ONE
Source Genre: Journal
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Publ. Info: 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA : PUBLIC LIBRARY SCIENCE
Pages: - Volume / Issue: 15 (3) Sequence Number: e0230380 Start / End Page: - Identifier: ISSN: 1932-6203