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  A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15th century Europe

Giffin, K., Lankapalli, A. K., Sabin, S., Spyrou, M. A., Posth, C., Kozakaitė, J., et al. (2020). A treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15th century Europe. Scientific Reports, 10(1): 9499. doi:10.1038/s41598-020-66012-x.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-92A4-B Version Permalink: http://hdl.handle.net/21.11116/0000-0006-92A5-A
Genre: Journal Article

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 Creators:
Giffin, Karen1, Author              
Lankapalli, Aditya Kumar1, Author              
Sabin, Susanna1, Author              
Spyrou, Maria A.1, Author              
Posth, Cosimo1, Author              
Kozakaitė, Justina, Author
Friedrich, Ronny, Author
Miliauskienė, Žydrūnė, Author
Jankauskas, Rimantas, Author
Herbig, Alexander1, Author              
Bos, Kirsten I.2, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2CoDisEASe, Max Planck Institute for the Science of Human History, Max Planck Society, ou_3033585              

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Free keywords: Bacteria, Genome, Microbial genetics, Microbiology, Pathogens
 Abstract: Developments in techniques for identification of pathogen DNA in archaeological samples can expand our resolution of disease detection. Our application of a non-targeted molecular screening tool for the parallel detection of pathogens in historical plague victims from post-medieval Lithuania revealed the presence of more than one active disease in one individual. In addition to Yersinia pestis, we detected and genomically characterized a septic infection of Treponema pallidum pertenue, a subtype of the treponemal disease family recognised as the cause of the tropical disease yaws. Our finding in northern Europe of a disease that is currently restricted to equatorial regions is interpreted within an historical framework of intercontinental trade and potential disease movements. Through this we offer an alternative hypothesis for the history and evolution of the treponemal diseases, and posit that yaws be considered an important contributor to the sudden epidemic of late 15th century Europe that is widely ascribed to syphilis.

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Language(s): eng - English
 Dates: 2020-06-11
 Publication Status: Published online
 Pages: 13
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1038/s41598-020-66012-x
Other: shh2635
 Degree: -

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Project name : CoDisEASe
Grant ID : 805268
Funding program : Horizon 2020 (H2020)
Funding organization : European Commission (EC)

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Title: Scientific Reports
  Abbreviation : Sci. Rep.
Source Genre: Journal
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Publ. Info: London, UK : Nature Publishing Group
Pages: - Volume / Issue: 10 (1) Sequence Number: 9499 Start / End Page: - Identifier: ISSN: 2045-2322
CoNE: https://pure.mpg.de/cone/journals/resource/2045-2322