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  A flexible workflow for simulating transcranial electric stimulation in healthy and lesioned brains

Kalloch, B., Bazin, P.-L., Villringer, A., Sehm, B., & Hlawitschka, M. (2020). A flexible workflow for simulating transcranial electric stimulation in healthy and lesioned brains. PLoS One, 15(5): e0228119. doi:10.1371/journal.pone.0228119.

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Kalloch, Benjamin1, 2, Author              
Bazin, Pierre-Louis1, 3, Author              
Villringer, Arno1, Author              
Sehm, Bernhard1, Author              
Hlawitschka, Mario1, 2, Author
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Faculty of Computer Science and Media, University of Applied Sciences, Germany, ou_persistent22              
3Faculty of Social and Behavioural Science, Cognitive Science Center Amsterdam, University of Amsterdam, the Netherlands, ou_persistent22              


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 Abstract: Simulating transcranial electric stimulation is actively researched as knowledge about the distribution of the electrical field is decisive for understanding the variability in the elicited stimulation effect. Several software pipelines comprehensively solve this task in an automated manner for standard use-cases. However, simulations for non-standard applications such as uncommon electrode shapes or the creation of head models from non-optimized T1-weighted imaging data and the inclusion of irregular structures are more difficult to accomplish. We address these limitations and suggest a comprehensive workflow to simulate transcranial electric stimulation based on open-source tools. The workflow covers the head model creation from MRI data, the electrode modeling, the modeling of anisotropic conductivity behavior of the white matter, the numerical simulation and visualization. Skin, skull, air cavities, cerebrospinal fluid, white matter, and gray matter are segmented semi-automatically from T1-weighted MR images. Electrodes of arbitrary number and shape can be modeled. The meshing of the head model is implemented in a way to preserve the feature edges of the electrodes and is free of topological restrictions of the considered structures of the head model. White matter anisotropy can be computed from diffusion-tensor imaging data. Our solver application was verified analytically and by contrasting the tDCS simulation results with that of other simulation pipelines (SimNIBS 3.0, ROAST 3.0). An agreement in both cases underlines the validity of our workflow. Our suggested solutions facilitate investigations of irregular structures in patients (e.g. lesions, implants) or new electrode types. For a coupled use of the described workflow, we provide documentation and disclose the full source code of the developed tools.


Language(s): eng - English
 Dates: 2020-01-022020-04-232020-05-14
 Publication Status: Published online
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 Rev. Type: -
 Identifiers: DOI: 10.1371/journal.pone.0228119
Other: eCollection 2020
PMID: 32407389
PMC: PMC7224502
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Funding organization : FAZIT-STIFTUNG
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Funding organization : International Max Planck Research School on the Neuroscience of Communication (IMPRS NeuroCom)

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Title: PLoS One
Source Genre: Journal
Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 15 (5) Sequence Number: e0228119 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850