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  Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum

Chen, Y., Sobczak, F., Pais-Roldán, P., Schwarz, C., Koretsky, A., & Yu, X. (2020). Mapping the Brain-Wide Network Effects by Optogenetic Activation of the Corpus Callosum. Cerebral Cortex, 30(11), 5885-5898. doi:10.1093/cercor/bhaa164.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-955F-8 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-1EA9-A
Genre: Journal Article

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Chen, Y1, 2, Author              
Sobczak, F1, 2, Author              
Pais-Roldán, P1, 2, Author              
Schwarz, C, Author
Koretsky, AP, Author
Yu, X1, 2, Author              
Affiliations:
1Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528695              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              

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 Abstract: Optogenetically driven manipulation of circuit-specific activity enables causality studies, but its global brain-wide effect is rarely reported. Here, we applied simultaneous functional magnetic resonance imaging (fMRI) and calcium recording with optogenetic activation of the corpus callosum (CC) connecting barrel cortices (BC). Robust positive BOLD was detected in the ipsilateral BC due to antidromic activity, spreading to the ipsilateral motor cortex (MC), and posterior thalamus (PO). In the orthodromic target, positive BOLD was reliably evoked by 2 Hz light pulses, whereas 40 Hz light pulses led to reduced calcium, indicative of CC-mediated inhibition. This presumed optogenetic CC-mediated inhibition was further elucidated by pairing light pulses with whisker stimulation at varied interstimulus intervals. Whisker-induced positive BOLD and calcium signals were reduced at intervals of 50/100 ms. The calcium-amplitude-modulation-based correlation with whole-brain fMRI signal revealed that the inhibitory effects spread to contralateral BC, ipsilateral MC, and PO. This work raises the need for fMRI to elucidate the brain-wide network activation in response to optogenetic stimulation.

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 Dates: 2020-062020-11
 Publication Status: Published in print
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1093/cercor/bhaa164
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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 30 (11) Sequence Number: - Start / End Page: 5885 - 5898 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440