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  Quantitative trait loci analysis (QTL) of seed specialized metabolites reveals seed-specific flavonols and differential regulation of glycoalkaloid content in tomato

Alseekh, S., Ofner, I., Liu, Z., Osorio, S., Vallarino, J. G., Last, R. L., et al. (2020). Quantitative trait loci analysis (QTL) of seed specialized metabolites reveals seed-specific flavonols and differential regulation of glycoalkaloid content in tomato. The Plant Journal, 103(6), 2007-2024. doi:10.1111/tpj.14879.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0007-0B08-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0007-0B09-4
Genre: Journal Article

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Alseekh, S.1, Author              
Ofner, Itai2, Author
Liu, Zhongyuan2, Author
Osorio, Sonia2, Author
Vallarino, J. G.1, Author              
Last, Robert L.2, Author
Zamir, Dani2, Author
Tohge, T.1, Author              
Fernie, A. R.1, Author              
Affiliations:
1Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              
2External Organizations, ou_persistent22              

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Free keywords: flavonol, tomato, steroidal glycoalkaloids, introgression lines, seeds, specialized metabolites
 Abstract: Summary Given the potential health benefits (and adverse effects), of polyphenolic and steroidal glycoalkaloids in the diet there is a growing interest in fully elucidating the genetic control of their levels in foodstuffs. Here we carried out profiling of the specialized metabolites in the seeds of the Solanum pennellii introgression lines identifying 338 putative metabolite quantitative trait loci (mQTL) for flavonoids, steroidal glycoalkaloids and further specialized metabolites. Two putative mQTL for flavonols and one for steroidal glycoalkaloids were cross-validated by evaluation of the metabolite content of recombinants harboring smaller introgression in the corresponding QTL interval or by analysis of lines from an independently derived backcrossed inbred line population. The steroidal glycoalkaloid mQTL was localized to a chromosomal region spanning 14 genes including a previously defined steroidal glycoalkaloid gene cluster. The flavonoid mQTL was further validated via the use of transient and stable overexpression of the Solyc12g098600 and Solyc12g096870 genes which encode seed specific UDP-glycosyltransferases (UGTs). The results are discussed in the context of our understanding of the accumulation of polyphenols and steroidal glycoalkaloids and how this knowledge may be incorporated into breeding strategies aimed at improving nutritional aspects of plants as well as in fortifying them against abiotic stress.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1111/tpj.14879
BibTex Citekey: doi:10.1111/tpj.14879
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Title: The Plant Journal
  Other : Plant J.
Source Genre: Journal
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Publ. Info: Oxford : Blackwell Science
Pages: - Volume / Issue: 103 (6) Sequence Number: - Start / End Page: 2007 - 2024 Identifier: ISSN: 0960-7412
CoNE: https://pure.mpg.de/cone/journals/resource/954925579095_1