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  Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes

Connah, L., Joshi, R., Vibhute, S., Gambino, G., Correia, J., & Angelovski, G. (2019). Solid-Phase-Supported Approach for the Preparation of Bioresponsive and Multifunctional MRI Probes. Organic Letters, 21(14), 5378-5382. doi:10.1021/acs.orglett.9b01341.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-9694-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-9695-8
Genre: Journal Article

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 Creators:
Connah, L1, 2, Author              
Joshi, R2, 3, Author              
Vibhute, S2, 3, Author              
Gambino, G1, 2, Author              
Correia, JDG, Author
Angelovski, G1, 2, Author              
Affiliations:
1Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_2528691              
2Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497794              
3Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society, ou_1497796              

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 Abstract: The development of bifunctional imaging probes can often be challenging with difficult and time-consuming solution phase chemistry protocols and purification techniques. A solid phase synthetic protocol was therefore utilized to produce a functionalized derivative of a potent bismacrocyclic calcium-responsive contrast agent for magnetic resonance imaging. Through a convenient building block approach, the applicability of this methodology in the preparation and simple future development of multifunctional imaging probes was demonstrated.

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 Dates: 2019-07
 Publication Status: Published in print
 Pages: -
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 Identifiers: DOI: 10.1021/acs.orglett.9b01341
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Title: Organic Letters
  Other : Org. Lett.
Source Genre: Journal
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Publ. Info: Washington, DC : American Chemical Society
Pages: - Volume / Issue: 21 (14) Sequence Number: - Start / End Page: 5378 - 5382 Identifier: ISSN: 1523-7060
CoNE: https://pure.mpg.de/cone/journals/resource/954925626338