English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Developing High Field MRI Contrast Agents by Tuning the Rotational Dynamics: Bisaqua GdAAZTA‐based Dendrimers

Tei, L., Gugliotta, G., Gambino, G., Fekete, M., & Botta, M. (2017). Developing High Field MRI Contrast Agents by Tuning the Rotational Dynamics: Bisaqua GdAAZTA‐based Dendrimers. Israel Journal of Chemistry, 57(9), 887-895. doi:10.1002/ijch.201700041.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-98CF-6 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-98D1-2
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Tei, L, Author
Gugliotta, G, Author
Gambino, G1, Author              
Fekete, M, Author
Botta, M, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Monomeric and dimeric AAZTA‐based bifunctional chelators (AAZTA=6‐amino‐6‐methylperhydro‐1,4‐diazepine tetraacetic acid) were attached to different generations (G0, G1 and G2) of ethylenediamine‐cored PAMAM dendrimers (PAMAM=polyamidoamine) to obtain a series of six dendrimeric systems with 4 to 32 chelates at the periphery. These GdIII‐loaded dendrimers have molecular weight ranging from 3.5 to 25 kDa, thus allowing a systematic investigation on the changes in relaxivity (r 1) with the variation of the rotational dynamics following the increase in molecular size. Variable‐temperature 17O NMR (on the dimeric building block Gd2L2 ) and 1H Nuclear Magnetic Relaxation Dispersion measurements at different temperatures indicate that the water exchange lifetime (τ M∼90 ns) of the two inner sphere water molecules does not represent a limiting factor to the relaxivity of the systems. The r 1 values at 1.5 T (60 MHz) and 298 K increases from 10.2 mM−1 s−1 for the monomer GdL1 to 31.4 mM−1 s−1 for the dendrimer Gd32G2‐32 (+308 %). However, the relaxivity (per Gd) does not show a linear dependence on the molecular mass, but rather the enhancement tends to attenuate markedly for larger systems. This effect has been attributed to the growing decrease in correlation between local rotational motions and global molecular tumbling.

Details

show
hide
Language(s):
 Dates: 2017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1002/ijch.201700041
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Israel Journal of Chemistry
  Other : Isr. J. Chem.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Weinheim : Wiley-VCH Verlag GmbH & Co. KGaA
Pages: - Volume / Issue: 57 (9) Sequence Number: - Start / End Page: 887 - 895 Identifier: ISSN: 0021-2148
CoNE: https://pure.mpg.de/cone/journals/resource/954925408770