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  An ancient view on host pathogen interaction across time and space

Barquera, R., & Krause, J. (2020). An ancient view on host pathogen interaction across time and space. Current Opinion in Immunology, 65, 65-69. doi:10.1016/j.coi.2020.05.004.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-9D95-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-9D96-0
Genre: Journal Article

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 Creators:
Barquera, Rodrigo1, Author              
Krause, Johannes2, Author              
Affiliations:
1Archaeogenetics, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2074310              
2MHAAM, Max Planck Institute for the Science of Human History, Max Planck Society, ou_2541699              

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 Abstract: The ancient DNA revolution provided diverse fields with an unprecedented opportunity to look back into the past and shed light on research aspects that were until now subject to speculation and inference from modern data. In particular enrichment methods that allow the targeted retrieval of millions of SNP positions from ancient human genomes, or even complete bacterial and viral genomes have the potential to revolutionize our understanding of host pathogen interactions. Ancient DNA combined with new bioinformatic tools now even allows actual allele calling for immunogenetic systems such as Human Leukocyte Antigen (HLA) across time and space. The coming years will provide us with frequency data of human immunity genes, such as HLA, as well as genome wide data of ancient pathogens from many time periods of human history, and will therefore provide us with a dynamic view on historical human adaptation to pathogen exposure on a population wide scale.

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Language(s): eng - English
 Dates: 2020-06-272020-08
 Publication Status: Published in print
 Pages: 5
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 Table of Contents: Introduction. - Testing the pathogen-driven selection. - Changes across time and space. - Going further back in time: the immunogenetic make-up of Pleistocene hominins. - conclusion
 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.coi.2020.05.004
Other: shh2643
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Title: Current Opinion in Immunology
  Other : Curr. Opin. Immunol.
Source Genre: Journal
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Publ. Info: Philadelphia, PA, USA : Elsevier Current Trends
Pages: - Volume / Issue: 65 Sequence Number: - Start / End Page: 65 - 69 Identifier: ISSN: 0952-7915
CoNE: https://pure.mpg.de/cone/journals/resource/954925575978