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  Metabolons, Enzyme-Enzyme Assemblies that Mediate Substrate Channeling, and Their Roles in Plant Metabolism

Zhang, Y., & Fernie, A. R. (2021). Metabolons, Enzyme-Enzyme Assemblies that Mediate Substrate Channeling, and Their Roles in Plant Metabolism. Plant Communications, 2: 100081. doi:10.1016/j.xplc.2020.100081.

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Genre: Journal Article

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 Creators:
Zhang, YJ1, Author              
Fernie, A. R.1, Author              
Affiliations:
1Central Metabolism, Department Willmitzer, Max Planck Institute of Molecular Plant Physiology, Max Planck Society, ou_1753339              

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Free keywords: Protein-protein interaction, Metabolon, substrate channeling
 Abstract: Metabolons are a specific type of transient multi-protein complex of sequential enzymes which mediate substrate channeling. They differ from multi-enzyme complexes in that they are dynamic rather than permanent and as such have considerably lower dissociation constants. Despite the fact that a huge number of metabolons have been claimed to exist in plants most of these claims are erroneous since only a handful of these have been proven to channel metabolites. We believe that physical protein- protein interactions between consecutive enzymes of a pathway should rather be called enzyme-enzyme assemblies. In this review we describe how metabolons are generally assembled by transient interaction and held together both by structural elements and non-covalent interactions. Experimental evidence for their existence comes from protein-protein interaction studies

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Language(s): eng - English
 Dates: 2021
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Plant Communications
Source Genre: Journal
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Publ. Info: -
Pages: 100081 Volume / Issue: 2 Sequence Number: 100081 Start / End Page: - Identifier: ISBN: 2590-3462