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  In situ architecture of the algal nuclear pore complex

Mosalaganti, S., Kosinski, J., Albert, S., Schaffer, M., Strenkert, D., Salomé, P. A., et al. (2018). In situ architecture of the algal nuclear pore complex. Nature Communications, 9(1): 2361. doi:10.1038/s41467-018-04739-y.

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 Creators:
Mosalaganti, Shyamal1, Author
Kosinski, Jan1, Author
Albert, Sahradha1, Author
Schaffer, Miroslava1, Author
Strenkert, Daniela1, Author
Salomé, Patrice A.1, Author
Merchant, Sabeeha S.1, Author
Plitzko, Jürgen M.1, Author
Baumeister, Wolfgang2, Author              
Engel, Benjamin D.1, Author
Beck, Martin3, Author              
Affiliations:
1External Organizations, ou_persistent22              
2Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565142              
3European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, ou_persistent22              

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Free keywords: Chlamydomonas reinhardtii, Evolution, Molecular, Nuclear Pore, Nuclear Pore Complex Proteins, Polymerization, Protein Structure, Quaternary
 Abstract: Nuclear pore complexes (NPCs) span the nuclear envelope and mediate nucleocytoplasmic exchange. They are a hallmark of eukaryotes and deeply rooted in the evolutionary origin of cellular compartmentalization. NPCs have an elaborate architecture that has been well studied in vertebrates. Whether this architecture is unique or varies significantly in other eukaryotic kingdoms remains unknown, predominantly due to missing in situ structural data. Here, we report the architecture of the algal NPC from the early branching eukaryote Chlamydomonas reinhardtii and compare it to the human NPC. We find that the inner ring of the Chlamydomonas NPC has an unexpectedly large diameter, and the outer rings exhibit an asymmetric oligomeric state that has not been observed or predicted previously. Our study provides evidence that the NPC is subject to substantial structural variation between species. The divergent and conserved features of NPC architecture provide insights into the evolution of the nucleocytoplasmic transport machinery.

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Language(s): eng - English
 Dates: 2017-11-012018-04-232018-06-18
 Publication Status: Published online
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1038/s41467-018-04739-y
BibTex Citekey: mosalaganti_situ_2018
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Title: Nature Communications
  Abbreviation : Nat. Commun.
Source Genre: Journal
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Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 9 (1) Sequence Number: 2361 Start / End Page: - Identifier: ISSN: 2041-1723
CoNE: https://pure.mpg.de/cone/journals/resource/2041-1723