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  Personality and local brain structure: Their shared genetic basis and reproducibility

Valk, S. L., Hoffstaedter, F., Camilleri, J. A., Kochunov, P., Yeo, B. T. T., & Eickhoff, S. B. (2020). Personality and local brain structure: Their shared genetic basis and reproducibility. NeuroImage, 220: 117067. doi:10.1016/j.neuroimage.2020.117067.

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 Urheber:
Valk, Sofie L.1, 2, 3, Autor           
Hoffstaedter, Felix1, 2, Autor
Camilleri, Julia A.1, 2, Autor
Kochunov, Peter4, Autor
Yeo, B. T. Thomas5, 6, 7, Autor
Eickhoff, Simon B.1, 2, Autor
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
3Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
4Maryland Psychiatric Research Center (MPRC), University of Maryland School of Medicine, Baltimore, MD, USA, ou_persistent22              
5Department of Electrical and Computer Engineering, Clinical Imaging Research Centre, National University of Singapore, ou_persistent22              
6Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
7NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, ou_persistent22              

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 Zusammenfassung: Local cortical architecture is highly heritable and distinct genes are associated with specific cortical regions. Total surface area has been shown to be genetically correlated with complex cognitive capacities, suggesting cortical brain structure is a viable endophenotype linking genes to behavior. However, to what extend local brain structure has a genetic association with cognitive and emotional functioning is incompletely understood. Here, we study the genetic correlation between personality traits and local cortical structure in a large-scale twin sample (Human Connectome Project, n ​= ​1102, 22-37y) and we evaluated whether observed associations reflect generalizable relationships between personality and local brain structure two independent age-matched samples (Brain Genomics Superstructure Project: n ​= ​925, age ​= ​19-35y, enhanced Nathan Kline Institute dataset: n ​= ​209, age: 19-39y). We found a genetic overlap between personality traits and local cortical structure in 10 of 18 observed phenotypic associations in predominantly frontal cortices. However, we only observed evidence in favor of replication for the negative association between surface area in medial prefrontal cortex and Neuroticism in both replication samples. Quantitative functional decoding indicated this region is implicated in emotional and socio-cognitive functional processes. In sum, our observations suggest that associations between local brain structure and personality are, in part, under genetic control. However, associations are weak and only the relation between frontal surface area and Neuroticism was consistently observed across three independent samples of young adults.

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Sprache(n): eng - English
 Datum: 2020-06-122020-05-082020-06-152020-06-202020-10-15
 Publikationsstatus: Erschienen
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 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: DOI: 10.1016/j.neuroimage.2020.117067
Anderer: epub 2020
PMID: 32574809
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Grant ID : 1FDN2012-1
Förderprogramm : -
Förderorganisation : Child Mind Institute
Projektname : -
Grant ID : R01MH081218; R01MH083246; R21MH084126
Förderprogramm : -
Förderorganisation : National Institute for Mental Health (NIMH)

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Titel: NeuroImage
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: Orlando, FL : Academic Press
Seiten: - Band / Heft: 220 Artikelnummer: 117067 Start- / Endseite: - Identifikator: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166