English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
 
 
DownloadE-Mail
  Personality and local brain structure: Their shared genetic basis and reproducibility

Valk, S. L., Hoffstaedter, F., Camilleri, J. A., Kochunov, P., Yeo, B. T. T., & Eickhoff, S. B. (2020). Personality and local brain structure: Their shared genetic basis and reproducibility. NeuroImage, 220: 117067. doi:10.1016/j.neuroimage.2020.117067.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/21.11116/0000-0006-9E86-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-9E87-0
Genre: Journal Article

Files

show Files
hide Files
:
Valk_2020.pdf (Publisher version), 2MB
Name:
Valk_2020.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Valk, Sofie L.1, 2, 3, Author              
Hoffstaedter, Felix1, 2, Author
Camilleri, Julia A.1, 2, Author
Kochunov, Peter4, Author
Yeo, B. T. Thomas5, 6, 7, Author
Eickhoff, Simon B.1, 2, Author
Affiliations:
1Institute of Neuroscience and Medicine, Research Center Jülich, Germany, ou_persistent22              
2Institute of Systems Neuroscience, University Hospital Düsseldorf, Germany, ou_persistent22              
3Otto Hahn Group Cognitive Neurogenetics, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_3222264              
4Maryland Psychiatric Research Center (MPRC), University of Maryland School of Medicine, Baltimore, MD, USA, ou_persistent22              
5Department of Electrical and Computer Engineering, Clinical Imaging Research Centre, National University of Singapore, ou_persistent22              
6Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, USA, ou_persistent22              
7NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Local cortical architecture is highly heritable and distinct genes are associated with specific cortical regions. Total surface area has been shown to be genetically correlated with complex cognitive capacities, suggesting cortical brain structure is a viable endophenotype linking genes to behavior. However, to what extend local brain structure has a genetic association with cognitive and emotional functioning is incompletely understood. Here, we study the genetic correlation between personality traits and local cortical structure in a large-scale twin sample (Human Connectome Project, n ​= ​1102, 22-37y) and we evaluated whether observed associations reflect generalizable relationships between personality and local brain structure two independent age-matched samples (Brain Genomics Superstructure Project: n ​= ​925, age ​= ​19-35y, enhanced Nathan Kline Institute dataset: n ​= ​209, age: 19-39y). We found a genetic overlap between personality traits and local cortical structure in 10 of 18 observed phenotypic associations in predominantly frontal cortices. However, we only observed evidence in favor of replication for the negative association between surface area in medial prefrontal cortex and Neuroticism in both replication samples. Quantitative functional decoding indicated this region is implicated in emotional and socio-cognitive functional processes. In sum, our observations suggest that associations between local brain structure and personality are, in part, under genetic control. However, associations are weak and only the relation between frontal surface area and Neuroticism was consistently observed across three independent samples of young adults.

Details

show
hide
Language(s): eng - English
 Dates: 2020-06-122020-05-082020-06-152020-06-202020-10-15
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.117067
Other: online ahead of print
PMID: 32574809
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : -
Grant ID : 1FDN2012-1
Funding program : -
Funding organization : Child Mind Institute
Project name : -
Grant ID : R01MH081218
Funding program : -
Funding organization : National Institute for Mental Health
Project name : -
Grant ID : R01MH083246
Funding program : -
Funding organization : National Institute for Mental Health
Project name : -
Grant ID : R21MH084126
Funding program : -
Funding organization : National Institute for Mental Health

Source 1

show
hide
Title: NeuroImage
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Orlando, FL : Academic Press
Pages: - Volume / Issue: 220 Sequence Number: 117067 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166