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  Intracellular morphogens: Specifying patterns at the subcellular scale

Hubatsch, L., & Goehring, N. W. (2020). Intracellular morphogens: Specifying patterns at the subcellular scale. In S. Small, & J. Briscoe (Eds.), Gradients and Tissue Patterning (pp. 247-278). Cambridge, MA: Elsevier.

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Item Permalink: https://hdl.handle.net/21.11116/0000-0006-CD95-B Version Permalink: https://hdl.handle.net/21.11116/0000-0006-CD96-A
Genre: Book Chapter

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 Creators:
Hubatsch, Lars1, Author           
Goehring, Nathan W.2, Author
Affiliations:
1Max Planck Institute for the Physics of Complex Systems, Max Planck Society, ou_2117288              
2external, ou_persistent22              

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 Abstract: The notion that graded distributions of signals underlie the spatial organization of biological systems has long been a central pillar in the fields of cell and developmental biology. During morphogenesis, morphogens spread across tissues to guide development of the embryo. Similarly, a variety of dynamic gradients and pattern-forming networks have been discovered that shape subcellular organization. Here we discuss the principles of intracellular pattern formation by these intracellular morphogens and relate them to conceptually similar processes operating at the tissue scale. We will specifically review mechanisms for generating cellular asymmetry and consider how intracellular patterning networks are controlled and adapt to cellular geometry. Finally, we assess the general concept of intracellular gradients as a mechanism for positional control in light of current data, highlighting how the simple readout of fixed concentration thresholds fails to fully capture the complexity of spatial patterning processes occurring inside cells.

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 Dates: 2020
 Publication Status: Issued
 Pages: -
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 Rev. Type: -
 Identifiers: ISI: 000532669100009
DOI: 10.1016/bs.ctdb.2019.11.006
 Degree: -

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Title: Gradients and Tissue Patterning
Source Genre: Book
 Creator(s):
Small , Stephen1, Editor
Briscoe , James1, Editor
Affiliations:
1 External Organizations, ou_persistent22            
Publ. Info: Cambridge, MA : Elsevier
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 247 - 278 Identifier: ISBN: 978-0-12-812791-9; 978-0-12-812790-2

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Title: Current Topics in Developmental Biology
Source Genre: Series
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Publ. Info: Cambridge, MA : Elsevier
Pages: - Volume / Issue: 137 Sequence Number: - Start / End Page: - Identifier: ISSN: 0070-2153