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  Structural relationships in the adenylate kinase family

Schulz, G. E., Schiltz, E., Tomasselli, A. G., Frank, R., Brune, M., Wittinghofer, A., et al. (1986). Structural relationships in the adenylate kinase family. European Journal of Biochemistry, 161(1), 127-132. doi:10.1111/j.1432-1033.1986.tb10132.x.

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EurJBiochem_161_1986_127.pdf (Any fulltext), 518KB
 
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Schulz, Georg E., Author
Schiltz, Emile, Author
Tomasselli, Alfredo G., Author
Frank, Rainer, Author
Brune, Martin1, Author           
Wittinghofer, Alfred2, 3, Author           
Schirmer, R. Heiner, Author
Affiliations:
1Max Planck Institute for Medical Research, Max Planck Society, ou_1125545              
2Emeritus Group Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497712              
3Sonstige Wissenschaftliche Organisationseinheiten, Max Planck Institute of Molecular Physiology, Max Planck Society, ou_1753294              

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 Abstract: The sequences of five distantly related adenylate kinases have been aligned. The local conservation of amino acids is discussed in the light of the known three-dimensional structure of one of the enzymes, the cytosolic isoenzyme 1 (AK1) from porcine muscle. The similarity profile outlines clearly the active site in the cleft of the spatial structure of AK1. The alignment reveals further that the enzyme family can be subdivided into small and large variants according to the presence or absence of a particular segment of about 30 residues in the middle of the chain. The extra segments of the large variants are strongly conserved

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Language(s): eng - English
 Dates: 1986-06-021986-08-132005-03-031986-11
 Publication Status: Issued
 Pages: 6
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 Rev. Type: Peer
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Title: European Journal of Biochemistry
Source Genre: Journal
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Publ. Info: Berlin : Published by Springer-Verlag on behalf of the Federation of European Biochemical Societies
Pages: - Volume / Issue: 161 (1) Sequence Number: - Start / End Page: 127 - 132 Identifier: ISSN: 0014-2956
CoNE: https://pure.mpg.de/cone/journals/resource/111097776606040