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  Fam20C regulates protein secretion by Cab45 phosphorylation

Hecht, T.-K.-H., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., et al. (2020). Fam20C regulates protein secretion by Cab45 phosphorylation. JOURNAL OF CELL BIOLOGY, 219(6): e201910089. doi:10.1083/jcb.201910089.

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Genre: Journal Article

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 Creators:
Hecht, Tobias Karl-Heinz1, Author              
Blank, Birgit1, Author              
Steger, Martin2, Author              
Lopez, Victor3, Author
Beck, Gisela1, Author              
Ramazanov, Bulat3, Author
Mann, Matthias2, Author              
Tagliabracci, Vincent3, Author
von Blume, Julia1, Author              
Affiliations:
1von Blume, Julia / Molecular Basis of Protein Trafficking, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565173              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              
3external, ou_persistent22              

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Free keywords: TRANS-GOLGI NETWORK; CARGO; TRAFFICKING; ADF/COFILIN; DOMAINS; COMPLEX; CALNUC; ACTIN; STATE; TGN
 Abstract: The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 client. Our findings demonstrate that Fam20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the TGN.

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Language(s): eng - English
 Dates: 2020
 Publication Status: Published online
 Pages: 26
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: ISI: 000538141100015
DOI: 10.1083/jcb.201910089
 Degree: -

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Title: JOURNAL OF CELL BIOLOGY
Source Genre: Journal
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Publ. Info: 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA : ROCKEFELLER UNIV PRESS
Pages: - Volume / Issue: 219 (6) Sequence Number: e201910089 Start / End Page: - Identifier: ISSN: 0021-9525