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  Virulence gene regulation by l-Arabinose in Salmonella enterica

López-Garrido, J., Puerta-Fernández, E., Cota, I., & Casadesús, J. (2015). Virulence gene regulation by l-Arabinose in Salmonella enterica. Genetics, 200(3), 807-819. doi:10.1534/genetics.115.178103.

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López-Garrido, Javier1, Author              
Puerta-Fernández, Elena, Author
Cota, Ignacio, Author
Casadesús, Josep, Author
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1External Organizations, ou_persistent22              

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 Abstract: Invasion of the intestinal epithelium is a critical step in Salmonella enterica infection and requires functions encoded in the gene cluster known as Salmonella Pathogenicity Island 1 (SPI-1). Expression of SPI-1 genes is repressed by l-arabinose, and not by other pentoses. Transport of l-arabinose is necessary to repress SPI-1; however, repression is independent of l-arabinose metabolism and of the l-arabinose-responsive regulator AraC. SPI-1 repression by l-arabinose is exerted at a single target, HilD, and the mechanism appears to be post-translational. As a consequence of SPI-1 repression, l-arabinose reduces translocation of SPI-1 effectors to epithelial cells and decreases Salmonella invasion in vitro. These observations reveal a hitherto unknown role of l-arabinose in gene expression control and raise the possibility that Salmonella may use L-arabinose as an environmental signal.

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Language(s): eng - English
 Dates: 2015-052015-07
 Publication Status: Published in print
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 Identifiers: DOI: 10.1534/genetics.115.178103
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Title: Genetics
Source Genre: Journal
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Publ. Info: Genetics Society of America
Pages: - Volume / Issue: 200 (3) Sequence Number: - Start / End Page: 807 - 819 Identifier: ISSN: 0016-6731
CoNE: https://pure.mpg.de/cone/journals/resource/954925400554