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  fMRI protocol optimization for simultaneously studying small subcortical and cortical areas at 7 ​T

Miletic, S., Bazin, P.-L., Weiskopf, N., van der Zwaag, W., Forstmann, B. U., & Trampel, R. (2020). fMRI protocol optimization for simultaneously studying small subcortical and cortical areas at 7 ​T. NeuroImage, 219: 116992. doi:10.1016/j.neuroimage.2020.116992.

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 Creators:
Miletic, Steven1, Author
Bazin, Pierre-Louis1, 2, Author              
Weiskopf, Nikolaus2, 3, Author              
van der Zwaag, Wietske4, Author
Forstmann, Birte U.1, Author
Trampel, Robert2, Author              
Affiliations:
1Department of Psychology, University of Amsterdam, the Netherlands, ou_persistent22              
2Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              
3Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany, ou_persistent22              
4Spinoza Centre for Neuroimaging, University of Amsterdam, the Netherlands, ou_persistent22              

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Free keywords: Cortex; Multi echo EPI; Single echo EPI; Stop-signal response task; Subcortex; fMRI protocol optimization
 Abstract: Most fundamental cognitive processes rely on brain networks that include both cortical and subcortical structures. Studying such networks using functional magnetic resonance imaging (fMRI) requires a data acquisition protocol that provides blood-oxygenation-level dependent (BOLD) sensitivity across the entire brain. However, when using standard single echo, echo planar imaging protocols, researchers face a tradeoff between BOLD-sensitivity in cortex and in subcortical areas. Multi echo protocols avoid this tradeoff and can be used to optimize BOLD-sensitivity across the entire brain, at the cost of an increased repetition time. Here, we empirically compare the BOLD-sensitivity of a single echo protocol to a multi echo protocol. Both protocols were designed to meet the specific requirements for studying small, iron rich subcortical structures (including a relatively high spatial resolution and short echo times), while retaining coverage and BOLD-sensitivity in cortical areas. The results indicate that both sequences lead to similar BOLD-sensitivity across the brain at 7 ​T.

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Language(s): eng - English
 Dates: 2020-05-142019-12-102020-05-202020-05-292020-10-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1016/j.neuroimage.2020.116992
Other: online ahead of print
PMID: 32480037
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Project name : -
Grant ID : 616905
Funding program : European Union’s Seventh Framework Programme (FP7/2007-2013)
Funding organization : European Research Council
Project name : -
Grant ID : 681094
Funding program : Horizon 2020
Funding organization : European Union

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Title: NeuroImage
Source Genre: Journal
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Pages: - Volume / Issue: 219 Sequence Number: 116992 Start / End Page: - Identifier: ISSN: 1053-8119
CoNE: https://pure.mpg.de/cone/journals/resource/954922650166