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  Anodal transcranial direct current stimulation over S1 differentially modulates proprioceptive accuracy in young and old adults

Muffel, T., Kirsch, F., Shih, P.-C., Kalloch, B., Schaumberg, S., Villringer, A., et al. (2019). Anodal transcranial direct current stimulation over S1 differentially modulates proprioceptive accuracy in young and old adults. Frontiers in Aging Neuroscience, 11: 264. doi:10.3389/fnagi.2019.00264.

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 Creators:
Muffel, Toni1, 2, 3, 4, 5, Author              
Kirsch, Franziska1, 6, Author
Shih, Pei-Cheng1, 7, Author              
Kalloch, Benjamin1, 7, 8, Author              
Schaumberg, Sara1, Author
Villringer, Arno1, 2, 3, 4, 5, 7, Author              
Sehm, Bernhard1, 2, 9, Author              
Affiliations:
1Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
2Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
3MindBrainBody Institute, Berlin School of Mind and Brain, Humboldt University Berlin, Germany, ou_persistent22              
4Center for Stroke Research, Charité University Medicine Berlin, Germany, ou_persistent22              
5International Max Planck Research School on the Life Course (LIFE), Max Planck Institute for Human Development, Max Planck Society, Lentzeallee 94, D-14195 Berlin, DE, ou_2074292              
6Institute of Psychology, Otto von Guericke University Magdeburg, Germany, ou_persistent22              
7International Max Planck Research School on Neuroscience of Communication, Leipzig, Germany, ou_persistent22              
8Faculty of Computer Science and Media, University of Applied Sciences, Leipzig, Germany, ou_persistent22              
9Department of Neurology, Martin Luther University Halle-Wittenberg, Germany, ou_persistent22              

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Free keywords: tDCS; Aging; Proprioception; Position sense; Robotics; Electrical field simulation
 Abstract: Background: Proprioception is a prerequisite for successful motor control but declines throughout the lifespan. Brain stimulation techniques such as anodal transcranial direct current stimulation (a-tDCS) are capable of enhancing sensorimotor performance across different tasks and age groups. Despite such growing evidence for a restorative potential of tDCS, its impact on proprioceptive accuracy has not been studied in detail yet. Objective: This study investigated online effects of a-tDCS over S1 on proprioceptive accuracy in young (YA) and old healthy adults (OA). Methods: The effect of 15 min of a-tDCS vs. sham on proprioceptive accuracy was assessed in a cross-over, double blind experiment in both age groups. Performance changes were tested using an arm position matching task in a robotic environment. Electrical field (EF) strengths in the target area S1 and control areas were assessed based on individualized simulations. Results: a-tDCS elicited differential changes in proprioceptive accuracy and EF strengths in the two groups: while YA showed a slight improvement, OA exhibited a decrease in performance during a-tDCS. Stronger EF were induced in target S1 and control areas in the YA group. However, no relationship between EF strength and performance change was found. Conclusion: a-tDCS over S1 elicits opposing effects on proprioceptive accuracy as a function of age, a result that is important for future studies investigating the restorative potential of a-tDCS in healthy aging and in the rehabilitation of neurological diseases that occur at advanced age. Modeling approaches could help elucidate the relationship between tDCS protocols, brain structure and performance modulation.

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Language(s): eng - English
 Dates: 2019
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnagi.2019.00264
PMID: 31611782
PMC: PMC6775783
 Degree: -

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Title: Frontiers in Aging Neuroscience
  Abbreviation : Front Aging Neurosci
Source Genre: Journal
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Pages: - Volume / Issue: 11 Sequence Number: 264 Start / End Page: - Identifier: ISSN: 1663-4365
CoNE: https://pure.mpg.de/cone/journals/resource/1663-4365