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  Tuning the thickness of a biomembrane by stapling diamidophospholipids with bolalipids

Drescher, S., Meister, A., Hause, G., Neuhaus, F., Balog, S., Brezesinski, G., et al. (2020). Tuning the thickness of a biomembrane by stapling diamidophospholipids with bolalipids. Langmuir, 36(29), 8610-8616. doi:10.1021/acs.langmuir.0c01522.

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Item Permalink: http://hdl.handle.net/21.11116/0000-0006-C54A-9 Version Permalink: http://hdl.handle.net/21.11116/0000-0006-E4EC-F
Genre: Journal Article

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 Creators:
Drescher, Simon, Author
Meister, Annette, Author
Hause, Gerd, Author
Neuhaus, Frederik, Author
Balog, Sandor, Author
Brezesinski, Gerald1, Author              
Zumbuehl, Andreas, Author
Affiliations:
1Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              

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Free keywords: Lipids, Membranes, Mixtures, Differential scanning calorimetry, Phase transitions
 Abstract: In a biological membrane, proteins require specificlipidsofdistinctive length and chain saturation surrounding them. The active tuning ofthe membrane thickness therefore opens new possibilities in the study andmanipulation of membrane proteins. Here, we introduce the concept of staplingphospholipids to different degrees of interdigitation depth by mixing 1,3-diamidophospholipids with single-chain bolalipids. The mixed membranes werestudied by calorimetric assays, electron microscopy, X-ray, and infrared measure-ments to provide a complete biophysical characterization of membrane stapling.The matching between the diamidophospholipids and the bolalipids can be sostrong as to completely induce a new phase that is more stable than the gel phase ofthe individual components.

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Language(s): eng - English
 Dates: 2020-07-012020
 Publication Status: Published in print
 Pages: -
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 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1021/acs.langmuir.0c01522
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Title: Langmuir
  Abbreviation : Langmuir
Source Genre: Journal
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Publ. Info: Columbus, OH : American Chemical Society
Pages: - Volume / Issue: 36 (29) Sequence Number: - Start / End Page: 8610 - 8616 Identifier: ISSN: 0743-7463