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  Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in recall response

Perona-Wright, G., Kohlmeier, J. E., Bassity, E., Freitas, T. C., Mohrs, K., Cookenham, T., et al. (2012). Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in recall response. Proceedings of the National Academy of Sciences of the United States of America, 109, 18535-18540. doi:10.1073/pnas.1119133109.

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Perona-Wright et al..pdf (Publisher version), 823KB
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https://www.pnas.org/content/109/45/18535 (Publisher version)
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 Creators:
Perona-Wright, Georgia1, Author
Kohlmeier, Jacob E.1, Author
Bassity, Elizabeth1, Author
Freitas, Tori C.1, Author
Mohrs, Katja1, Author
Cookenham, Tres1, Author
Situ, Haozhong1, Author
Pearce, Edward J.2, Author           
Woodland, David L.1, Author
Mohrs, Markus1, Author
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1External Organizations, ou_persistent22              
2Department Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, ou_2243648              

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Free keywords: immune regulation, T-cell differentiation, IL-10 reporter mice, influenza, Sendai virus
 Abstract: CD8+ T cells are central to the eradication of intracellular pathogens, but they can also act to limit inflammation and immunopathology. During primary respiratory viral infection CD8+ effector T cells release the immunosuppressive cytokine IL-10, which is essential for host survival. Here we report that CD8+ T-cell–derived IL-10 is absent in a recall response. We show in mice that the lack of IL-10 is due to a persistent loss of IL-27 responsiveness in CD8+ memory T cells, caused by down-regulation of the common cytokine receptor, glycoprotein 130. CD8+ memory T cells secreted less IL-10 when activated in the presence of IL-27 than did naïve controls, and retroviral expression of glycoprotein 130 restored IL-10 and reduced IFN-γ production upon restimulation. We demonstrate that human CD8+memory cells are also characterized by impaired IL-27 responsiveness. Our data suggest that CD8+ T-cell activation involves a persistent loss of specific cytokine receptors that determines the functional potential of these cells during rechallenge infection.

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Language(s): eng - English
 Dates: 2012
 Publication Status: Issued
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1073/pnas.1119133109
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Title: Proceedings of the National Academy of Sciences of the United States of America
  Other : Proc. Acad. Sci. USA
  Other : Proc. Acad. Sci. U.S.A.
  Other : Proceedings of the National Academy of Sciences of the USA
  Abbreviation : PNAS
Source Genre: Journal
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Publ. Info: Washington, D.C. : National Academy of Sciences
Pages: - Volume / Issue: 109 Sequence Number: - Start / End Page: 18535 - 18540 Identifier: ISSN: 0027-8424
CoNE: https://pure.mpg.de/cone/journals/resource/954925427230